Document Detail


European randomized, multicenter study of goserelin (Zoladex) in the management of mastalgia.
MedLine Citation:
PMID:  15592276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Breast pain is a common symptom in patients attending breast clinics. The purpose of this study was to evaluate the efficacy of goserelin (Zoladex) as compared with sham injection in patients with mastalgia. STUDY DESIGN: One hundred forty-seven premenopausal women were randomized to treatment with either goserelin injection (3.6 mg/month) or sham injection for a total of 6 injections. Patients' daily self-assessment of breast pain using Cardiff breast pain chart was recorded during the 6-month treatment period and for 6 months in the posttreatment period. RESULTS: A significant treatment difference between the 2 groups in favor of goserelin was noted during the treatment period. Mean breast pain score improved by 67% in the goserelin group and 35% in the sham group during the treatment period. The mean pain scores increased in both groups in the posttreatment period. No significant posttreatment difference was found between the two groups. Side effects were more common with goserelin than sham injection. Patients receiving goserelin experienced vaginal dryness, hot flushes, decreased libido, oily skin or hair, and a decrease in breast size more frequently than sham patients. CONCLUSION: Goserelin is an effective short-term treatment for mastalgia. However, side effects are common, and thus, goserelin should be kept in reserve for patients who are refractory to other forms of treatment. Potentially, goserelin could be used to induce a rapid relief of symptoms that could be maintained with alternative therapies.
Authors:
Robert E Mansel; Amit Goyal; Paul Preece; Sam Leinster; Paul R Maddox; Christopher Gateley; Ernst Kubista; Dietrich von Fournier
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1942-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom. ManselRE@cf.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Breast Diseases / diagnosis,  drug therapy*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Goserelin / therapeutic use*
Humans
Injections, Subcutaneous
Middle Aged
Pain / diagnosis,  drug therapy*
Pain Measurement
Patient Satisfaction
Probability
Risk Assessment
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
65807-02-5/Goserelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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