Document Detail


European multicentre study in children born small for gestational age with persistent short stature: comparison of continuous and discontinuous growth hormone treatment regimens.
MedLine Citation:
PMID:  19039237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The most effective growth hormone (GH) treatment regimen for increasing height in short children born small for gestational age (SGA) has not been well defined. METHODS: Short SGA children (n = 151, age 3-8 years, height less than -2.5 standard deviation scores) were randomised to receive low-dose GH for 2 years (0.033/0.033 mg/kg/day, n = 51), high-dose GH for 1 year and then no treatment for 1 year (0.100/0 mg/kg/day, n = 51) or were untreated for 1 year then received mid-dose GH for 1 year (0/0.067 mg/kg/day, n = 47). Height, bone age and adverse events were determined at check-ups every 3 months. RESULTS: The mean +/- SD additional height gain with GH after 1 year, relative to untreated controls, was higher with discontinuous high-dose than with continuous low-dose GH (6.5 +/- 0.2 vs. 3.3 +/- 0.2 cm). After 2 years, the additional height gain was similar between high- and low-dose GH groups (between-group treatment difference = 0.2, 95% CI = -0.8 to 1.2 cm, p = 0.702). Patients treated exclusively in the last year had a similar height gain to those in the other treatment groups (p = 0.604). CONCLUSIONS: In short SGA children, continuous low-dose and discontinuous high-dose GH regimens were associated with similar height gain. Treatment with mid-dose GH for 1 year also led to a similar improvement in growth.
Authors:
Moshe Phillip; Yael Lebenthal; Jan Lebl; Nehama Zuckerman-Levin; Maria Korpal-Szczyrska; Jorge Sales Marques; Adam Steensberg; Kirsten Jons; Anne-Marie Kappelgaard; Lourdes Ibanez;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-11-27
Journal Detail:
Title:  Hormone research     Volume:  71     ISSN:  1423-0046     ISO Abbreviation:  Horm. Res.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-20     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  52-9     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Affiliation:
Institute for Endocrinology and Diabetes, Schneider Children's Medical Center of Israel and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. mosheph@post.tau.ac.il
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Body Height / drug effects*
Child
Child, Preschool
Double-Blind Method
Female
Growth Disorders / blood,  drug therapy*
Hemoglobin A, Glycosylated / metabolism
Human Growth Hormone / administration & dosage*
Humans
Infant, Newborn
Infant, Small for Gestational Age*
Injections, Subcutaneous
Insulin / blood
Insulin-Like Growth Factor Binding Proteins / blood
Insulin-Like Growth Factor I / metabolism
Longitudinal Studies
Male
Prospective Studies
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Proteins; 11061-68-0/Insulin; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I
Investigator
Investigator/Affiliation:
Leo Dunkel / ; Marita Lipsanen-Nyman / ; Ilkka Sipilä / ; Timo Otonkoski / ; Risto Lapatto / ; Raimo Voutilainen / ; Sirpa Tenhola / ; Ulla Sankilampi / ; Päivi Tapanainen / ; Riitta Veijola / ; Jirina Zapletalova / ; Dana Novotna / ; Jaroslav Skvor / ; Ustí nad Labem / ; Jan Lebl / ; Stanislava Kolouskova / ; Bozena Kalvachova / ; Ester Liberman / ; Eli Hershkovitz / ; Neta Loewenthal / ; Moshe Phillip / ; Yael Lebenthal / ; Zvi Zadik / ; Amnon Zang / ; Ze'ev Hochberg / ; Nehama Zukerman-Levin / ; Dov Tiosano / ; Tomasz Romer / ; Alicja Korpysz / ; Jerzy Starzyk / ; Agata Zygmunt Górska / ; Malgorzata Kumorowicz-Kopiec / ; Dominika Januś / ; Dorota Roztoczyńska / ; Anna Kalicka-Kasperczyk / ; Aleksandra Górska / ; Katarzyna Dolezal-Oltarzewska / ; Dorota Bilecka / ; Edyta Piatkowska / ; Maria Korpal-Szczyrska / ; Bohdana Dorant / ; Halina Kamińska / ; Dorota Birkholz / ; Eberhard Keller / ; Johannes Weigel / ; Alexandra Keller / ; Sabine Liebermann / ; Klaus-Peter Ullrich / ; Stefan Wirth / ; Philip Wintermeyer / ; Manuel Jorge Fontoura Pinheiro de Magalhães / ; Cíntia Gonçalves Castro-Correia / ; ario Aires Marcelo da Fonseca / ; Luis Francisco Simões de Moura / ; Maria Alice Santos Cordeiro Mirante / ; Jorge Manuel Sales Marques / ; Jacinto Américo Silva Torres / ; Rosa Arménia Martins Campos / ; Marta Vila Real Magalhães Coelho / ; Vila Nova de Gaia / ; Jesús Argente Oliver / ; Jesús Pozo / ; Ricardo Gracia Bouthelier / ; Antonio Oliver Iguacel / ; Amparo Rodriguez Sánchez / ; Dolores Rodríguez Arnao / ; Concepción Carles Genotes / ; Vicente Albiach / ; Antonio Carrascosa Lezcano / ; Diego Yeste / ; Francisco Rodríguez-Hierro / ; Lourdes Ibanez / ; Juan Manuel Fernández García / ; Carlos Ruiz / ; Juan Pedro López-Siguero / ; María José Martinez Aedo / ; Almudena del Pino / ; Manuel Pombo Arias / ; Jesús Barreiro Conde / ; Olle Söder / ; Eva Horemizová / ; Jan Aman / ; Mirek Vejvoda / ; Christian Penno /

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