Document Detail


European genetic ancestry is associated with a decreased risk of lupus nephritis.
MedLine Citation:
PMID:  23023776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: African Americans, East Asians, and Hispanics with systemic lupus erythematosus (SLE) are more likely to develop renal disease than are SLE patients of European descent. This study was undertaken to investigate whether European genetic ancestry protects against the development of lupus nephritis, with the aim of exploring the genetic and socioeconomic factors that might explain this effect.
METHODS: This was a cross-sectional study of SLE patients from a multiethnic case collection. Participants were genotyped for 126 single-nucleotide polymorphisms (SNPs) informative for ancestry. A subset of participants was also genotyped for 80 SNPs in 14 candidate genes for renal disease in SLE. Logistic regression was used to test the association between European ancestry and renal disease. Analyses were adjusted for continental ancestries, socioeconomic status (SES), and candidate genes.
RESULTS: Participants (n = 1,906) had, on average, 62.4% European, 15.8% African, 11.5% East Asian, 6.5% Amerindian, and 3.8% South Asian ancestry. Among the participants, 656 (34%) had renal disease. A 10% increase in the proportion of European ancestry estimated in each participant was associated with a 15% reduction in the odds of having renal disease, after adjustment for disease duration and sex (odds ratio 0.85, 95% confidence interval 0.82-0.87; P = 1.9 × 10(-30) ). Adjustment for other genetic ancestries, measures of SES, or SNPs in the genes most associated with renal disease (IRF5 [rs4728142], BLK [rs2736340], STAT4 [rs3024912], and HLA-DRB1*0301 and DRB1*1501) did not substantively alter this relationship.
CONCLUSION: European ancestry is protective against the development of renal disease in SLE, an effect that is independent of other genetic ancestries, candidate risk alleles, and socioeconomic factors.
Authors:
Ilana B Richman; Kimberly E Taylor; Sharon A Chung; Laura Trupin; Michelle Petri; Edward Yelin; Robert R Graham; Annette Lee; Timothy W Behrens; Peter K Gregersen; Michael F Seldin; Lindsey A Criswell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  64     ISSN:  1529-0131     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-01-16     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3374-82     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics
Alleles
Asian Continental Ancestry Group / genetics
Cross-Sectional Studies
European Continental Ancestry Group / genetics*
Female
Genetic Predisposition to Disease*
Genotype*
HLA Antigens / genetics
Humans
Lupus Nephritis / genetics*
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk
Grant Support
ID/Acronym/Agency:
AR-43727/AR/NIAMS NIH HHS; K24 AR002175/AR/NIAMS NIH HHS; K24-AR-0217/AR/NIAMS NIH HHS; KL2 RR024130/RR/NCRR NIH HHS; M01 RR000079/RR/NCRR NIH HHS; M01-RR-0079/RR/NCRR NIH HHS; P60 AR053308/AR/NIAMS NIH HHS; P60-AR-053308/AR/NIAMS NIH HHS; R01 AR043727/AR/NIAMS NIH HHS; R01 AR044804/AR/NIAMS NIH HHS; R01-AR-44804/AR/NIAMS NIH HHS; RR-024130/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/HLA Antigens
Comments/Corrections

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