Document Detail


European Stroke Prevention Study (ESPS): antithrombotic therapy is also effective in the elderly.
MedLine Citation:
PMID:  8442393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ESPS was a multicenter study comparing the effect of the combination of dipyridamole 75 mg and acetylsalicylic acid 330 mg t.i.d. to placebo in 2500 patients (intention-to-treat analysis) and 1861 patients (explanatory analysis) in the secondary prevention of stroke or death after one or more attacks of TIA, RIND or stroke of atherothrombotic origin. End-point reduction was evaluated in two age groups, those not older than 65 years (1358 patients) and those who were older than 65 years (1142 patients). End-point reduction was significantly greater in patients with active therapy than in the placebo group in both age groups. Subgroup analyses with stroke as an end-point indicated that younger patients with TIA (< or = 65 years) had lower risk of stroke than those > 65 years or patients with stroke. The overall risk reduction was best in TIA patients > 65 years of age. The risk reduction with study medication was 40-50% in both sexes and in both age groups. Thus, age of the patient does not influence the efficacy of antithrombotic therapy. However, since these results are obtained from a secondary analysis of a subgroup of patients, the results may need confirmation by further studies.
Authors:
J Sivenius; P J Riekkinen; M Laakso; P Smets; A Lowenthal
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  87     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-30     Completed Date:  1993-03-30     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Actuarial Analysis
Aged
Aspirin / administration & dosage*
Cause of Death
Cerebral Infarction / mortality,  prevention & control
Cerebrovascular Disorders / mortality,  prevention & control*
Dipyridamole / administration & dosage*
Double-Blind Method
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Intracranial Embolism and Thrombosis / mortality,  prevention & control
Ischemic Attack, Transient / mortality,  prevention & control
Male
Recurrence
Survival Rate
Chemical
Reg. No./Substance:
50-78-2/Aspirin; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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