Document Detail

European Palliative Care Research collaborative pain guidelines. Central side-effects management: what is the evidence to support best practice in the management of sedation, cognitive impairment and myoclonus?
MedLine Citation:
PMID:  20870687     Owner:  NLM     Status:  In-Data-Review    
This is a systematic review examining the management of opioid-induced central side effects. It has been conducted as part of a larger European Palliative Care Research collaborative review into the use and role of opioids in cancer pain. The review process identified 26 studies that met the inclusion criteria. The overall quality of the data was low and the few recommendations that can be made are weak and require confirmatory studies. The main central side effects examined were sedation, cognitive failure, sleep disturbance and myoclonus. Overall there is limited evidence for the use of methylphenidate in counteracting opioid-induced sedation and cognitive disturbance. No clear recommendations can be made concerning other individual drugs for the management of any of the central side effects examined. Given the lack of available data from this review there need to be further prospective controlled trials to confirm or refute these findings.
Patrick Stone; Ollie Minton
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Publication Detail:
Type:  Journal Article     Date:  2010-09-24
Journal Detail:
Title:  Palliative medicine     Volume:  25     ISSN:  1477-030X     ISO Abbreviation:  Palliat Med     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704926     Medline TA:  Palliat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-41     Citation Subset:  IM    
Division of Mental Health, St Georges University of London, UK.
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