Document Detail


European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation.
MedLine Citation:
PMID:  23625942     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with non-valvular atrial fibrillation (AF). Both physicians and patients will have to learn how to use these drugs effectively and safely in clinical practice. Many unresolved questions on how to optimally use these drugs in specific clinical situations remain. The European Heart Rhythm Association set out to coordinate a unified way of informing physicians on the use of the different NOACs. A writing group listed 15 topics of concrete clinical scenarios and formulated as practical answers as possible based on available evidence. The 15 topics are: (1) Practical start-up and follow-up scheme for patients on NOACs; (2) How to measure the anticoagulant effect of NOACs; (3) Drug-drug interactions and pharmacokinetics of NOACs; (4) Switching between anticoagulant regimens; (5) Ensuring compliance of NOAC intake; (6) How to deal with dosing errors; (7) Patients with chronic kidney disease; (8) What to do if there is a (suspected) overdose without bleeding, or a clotting test is indicating a risk of bleeding? (9) Management of bleeding complications; (10) Patients undergoing a planned surgical intervention or ablation; (11) Patients undergoing an urgent surgical intervention; (12) Patients with AF and coronary artery disease; (13) Cardioversion in a NOAC-treated patient; (14) Patients presenting with acute stroke while on NOACs; (15) NOACs vs. VKAs in AF patients with a malignancy. Since new information is becoming available at a rapid pace, an EHRA Web site with the latest updated information accompanies this text (www.NOACforAF.eu).
Authors:
Hein Heidbuchel; Peter Verhamme; Marco Alings; Matthias Antz; Werner Hacke; Jonas Oldgren; Peter Sinnaeve; A John Camm; Paulus Kirchhof;
Publication Detail:
Type:  Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  15     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-11-05     Revised Date:  2014-02-03    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  625-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Anticoagulants / administration & dosage*
Atrial Fibrillation / complications*,  drug therapy*
Cardiology / standards*
Europe
Heart Valve Diseases / complications,  drug therapy
Thrombosis / etiology*,  prevention & control*
Chemical
Reg. No./Substance:
0/Anticoagulants
Comments/Corrections
Comment In:
Europace. 2014 Jan;16(1):149   [PMID:  24072444 ]
Europace. 2014 Jan;16(1):149-50   [PMID:  24072449 ]
Europace. 2014 Jan;16(1):151-2   [PMID:  24344327 ]
Europace. 2014 Jan;16(1):150-1   [PMID:  24344326 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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