Document Detail

Eukaryotic translation initiation factor 4E (eIF4E) expression in the brain tissue is induced by infusion of nerve growth factor into the mouse cisterna magnum: an in vivo study.
MedLine Citation:
PMID:  17684707     Owner:  NLM     Status:  MEDLINE    
In many cell types translation can be regulated by an expression of the translation initiation factor. Eukaryotic translation initiation factor eIF4E, which binds to the 5' cap structure of mRNA, plays an important role in translation regulation and it has been suggested that it is implicated in increased protein synthesis promoted by growth factors. In this study the effects of nerve growth factor (NGF) infusion into the cerebrospinal fluid (CSF) on eIF4E expression and phosphorylation in mouse brain tissue have been investigated. We investigated NGF as it is one of the most important growth factors and it is an important factor in cerebral cortical development, stimulating neuronal precursor proliferation. eIF4E level is also increased in response to infusion of NGF into the CSF. The present study shows that eIF4E is phosphorylated in the brain tissues treated with NGF. It is concluded that NGF regulates protein synthesis in the nervous tissue by enhancing expression and phosphorylation of eIF4E.
Zivar Salehi; Farhad Mashayekhi
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Publication Detail:
Type:  Journal Article     Date:  2007-08-08
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  304     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2008-02-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
Department of Biology, Faculty of Science, The University of Guilan, Rasht, Iran.
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MeSH Terms
Animals, Newborn
Cisterna Magna / drug effects*,  metabolism
Eukaryotic Initiation Factor-4E / chemistry,  metabolism*
Gene Expression / drug effects
Injections, Intraventricular
Isoelectric Focusing
Mice, Inbred BALB C
Nerve Growth Factor / administration & dosage*
Protein Kinases / metabolism
Reg. No./Substance:
0/Eukaryotic Initiation Factor-4E; 9061-61-4/Nerve Growth Factor; EC 2.7.-/Protein Kinases

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