Document Detail


Eukaryotic transcriptional dynamics: from single molecules to cell populations.
MedLine Citation:
PMID:  23835438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transcriptional regulation is achieved through combinatorial interactions between regulatory elements in the human genome and a vast range of factors that modulate the recruitment and activity of RNA polymerase. Experimental approaches for studying transcription in vivo now extend from single-molecule techniques to genome-wide measurements. Parallel to these developments is the need for testable quantitative and predictive models for understanding gene regulation. These conceptual models must also provide insight into the dynamics of transcription and the variability that is observed at the single-cell level. In this Review, we discuss recent results on transcriptional regulation and also the models those results engender. We show how a non-equilibrium description informs our view of transcription by explicitly considering time- and energy-dependence at the molecular level.
Authors:
Antoine Coulon; Carson C Chow; Robert H Singer; Daniel R Larson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review     Date:  2013-07-09
Journal Detail:
Title:  Nature reviews. Genetics     Volume:  14     ISSN:  1471-0064     ISO Abbreviation:  Nat. Rev. Genet.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-18     Completed Date:  2013-10-21     Revised Date:  2014-10-11    
Medline Journal Info:
Nlm Unique ID:  100962779     Medline TA:  Nat Rev Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  572-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
DNA-Directed RNA Polymerases / genetics,  metabolism
Gene Expression Regulation*
Genome, Human*
Humans
Transcription Factors / genetics*,  metabolism
Transcription, Genetic*
Grant Support
ID/Acronym/Agency:
84364//PHS HHS; 86217//PHS HHS; GM57071/GM/NIGMS NIH HHS; R01 GM057071/GM/NIGMS NIH HHS; R01 GM084364/GM/NIGMS NIH HHS; R01 GM086217/GM/NIGMS NIH HHS; ZIA DK075069-01/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Transcription Factors; EC 2.7.7.6/DNA-Directed RNA Polymerases
Comments/Corrections

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