| Euglycemic hyperinsulinemia increases glucose 1,6-bisphosphate in human skeletal muscle. | |
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MedLine Citation:
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PMID: 2684699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The effects of physiologic concentrations of insulin on the contents of glucose 1,6-bisphosphate (glucose 1,6-P2) and regulators of glucose 1,6-P2 synthase in intact human skeletal muscle have been investigated. 2. Insulin increased glucose 1,6-P2 from a basal value of 70 +/- 6 to 135 +/- 12 mumol/kg dry wt (P less than 0.001). 3. Activation of synthase could not be associated with changes in its inhibitors (fructose 1,6-P2, Pi, citrate) or its substrate glucose 6-P. |
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Authors:
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A Katz; B L Nyomba; C Bogardus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of biochemistry Volume: 21 ISSN: 0020-711X ISO Abbreviation: Int. J. Biochem. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-12-27 Completed Date: 1989-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0250365 Medline TA: Int J Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1079-82 Citation Subset: IM |
Affiliation:
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Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, Phoenix, AZ 85016. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Blood Glucose / metabolism Glucose-6-Phosphate* / analogs & derivatives* Glucosephosphates / metabolism* Humans Insulin / blood*, pharmacology Male Muscles / drug effects, metabolism* Phosphates / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Glucosephosphates; 0/Phosphates; 0/glucose-1,6-bisphosphate; 11061-68-0/Insulin; 56-73-5/Glucose-6-Phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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