| Eudragit EPO nanoparticles: Application in improving therapeutic efficacy and reducing ulcerogenicity of meloxicam on oral administration. | |
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MedLine Citation:
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PMID: 21870464 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The objective of this investigation was to evaluate the potential of Eudragit EPO nanoparticles (EPO NP) in improving therapeutic efficacy of meloxicam (MLX). MLX loaded EPO NP were prepared by nanoprecipitation method and were characterized for particle size, encapsulation efficiency and for morphology. The in vitro dissolution profile of MLX loaded EPO NP and MLX suspension was evaluated. MLX loaded EPO NP had particle size of approximately 100 nm and the encapsulation efficiency of MLX was approximately 90%. The EPO NP significantly improved anti-inflammatory activity of MLX (P < 0.01) as compared to that of MLX suspension. The enhanced anti-inflammatory effect was maintained for a longer duration (6 h) in case of MLX loaded EPO NP Oral administration of MLX loaded EPO NP also resulted in lesser ulcerogenicity as compared to that of MLX suspension indicating that nanoparticles can also decrease the adverse effects associated with MLX treatment. |
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Authors:
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Parag Khachane; Abhijit A Date; Mangal S Nagarsenker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical nanotechnology Volume: 7 ISSN: 1550-7033 ISO Abbreviation: J Biomed Nanotechnol Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230869 Medline TA: J Biomed Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 590-7 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E.), Mumbai 400098, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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