| Eucommiae Cortex Inhibits TNF-α and IL-6 Through the Suppression of Caspase-1 in Lipopolysaccharide-Stimulated Mouse Peritoneal Macrophages. | |
| | |
MedLine Citation:
|
PMID: 22298454 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Eucommiae cortex (EC) is used in various traditional Korean medicines in the form of tonics, analgesics, and sedatives. However, the underlying mechanism of its anti-inflammatory effect remains unclear. This study attempts to determine the effects of EC on lipopolysaccharide (LPS)-induced inflammatory responses in mouse peritoneal macrophages. The findings of the study show that EC inhibits the LPS-induced production of tumor necrosis factor-alpha and interleukin-6. Exposure to EC also reduces an inflammation-induced increase in the levels of cyclooxigenase-2 and the production of prostaglandin E(2) and nitric oxide in mouse peritoneal macrophages. Furthermore, EC suppresses the activation of nuclear factor-kappa B and caspase-1. These results provide novel insights into the pharmacological action of EC and indicate that EC has a potential in the treatment of inflammatory diseases. |
| | |
Authors:
|
Min-Cheol Kim; Dae-Seung Kim; Su-Jin Kim; Jinbong Park; Hye-Lin Kim; Seon-Young Kim; Kwang Seok Ahn; Hyeung-Jin Jang; Seok-Geun Lee; Kang-Min Lee; Seung-Heon Hong; Jae-Young Um |
Related Documents
:
|
22530124 - The role of cytokines and inflammatory cells in perinatal brain injury. 2464644 - Hla-restricted lysis of herpes simplex virus-infected monocytes and macrophages mediate... 11449074 - Mannan mucin-1 peptide immunization: influence of cyclophosphamide and the route of inj... 21312124 - Human eosinophil isolation and the measurement of apoptosis. 16143094 - Connecting mitochondria and innate immunity. 7517174 - Control of sensitivity to induction of apoptosis in myeloid leukemic cells by different... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of Chinese medicine Volume: 40 ISSN: 0192-415X ISO Abbreviation: Am. J. Chin. Med. Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7901431 Medline TA: Am J Chin Med Country: Singapore |
Other Details:
|
Languages: eng Pagination: 135-49 Citation Subset: IM |
Affiliation:
|
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Jeonbuk 570-749, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An improved acute gouty arthritis rat model and therapeutic effect of rhizoma dioscoreae nipponicae ...
Next Document: Cimicifuga foetida L. Inhibited Human Respiratory Syncytial Virus in HEp-2 and A549 Cell Lines.