| Etretinate therapy stimulates deposition of mucus-like material in epidermis of patients with psoriasis. | |
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MedLine Citation:
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PMID: 7068978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During therapy for psoriasis with the oral aromatic retinoid etretinate, a finely granular material was detected by electron microscopic examination of the epidermis of ten patients. Since this amorphous substance has some of the ultrastructural characteristics of mucin, it is called mucus-like material (MLM). MLM occurs occasionally in untreated psoriatic lesions; however, its deposition is enhanced by etretinate therapy. While MLM has not been fully characterized, evidence exists for the possibilities that it represents either cell products (such as mucin, or carbohydrates associated with the cell surface) or an exudate infiltrating the epidermis. |
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Authors:
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C N Ellis; R C Gold; R C Grekin; T F Anderson; N A Swanson; J J Voorhees |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 6 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1982-06-24 Completed Date: 1982-06-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 699-704 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Etretinate
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therapeutic use* Histocytochemistry Humans Mucus / metabolism* Psoriasis / drug therapy*, metabolism, pathology Skin / metabolism*, ultrastructure Tretinoin / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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302-79-4/Tretinoin; 54350-48-0/Etretinate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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