Document Detail


Etoposide-related acute promyelocytic leukemia.
MedLine Citation:
PMID:  9697869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of therapy-related acute myeloid leukemia (t-AML) has become a growing concern over the past decade, because of the increase in the percentage of long-term survivors of primary malignancy. We reviewed 17 cases with etoposide-related acute promyelocytic leukemia (APL) reported in the literature. The close association between treatment with etoposide for Langerhans cell histiocytosis (LCH) and the development of etoposide-related APL was demonstrated among Japanese and Italians. Our data on the breakpoints (b/ps) of the PML and RARalpha genes are presented. It is suggested that chromatin structure might be more important than specific consensus sequence in the distribution of b/ps in etoposide-related APL.
Authors:
K Kudo; H Yoshida; H Kiyoi; S Numata; K Horibe; T Naoe
Related Documents :
18254899 - 'indotest' in atypical hemicrania continua.
3933239 - Chronic myeloid leukemia with an unusual simple variant translocation: t(22;22)(q13;q11).
12034519 - Mll amplification in myeloid malignancies: clinical, molecular, and cytogenetic findings.
2374439 - Isochromosome 11q in a case of acute myelomonocytic leukemia fab type m4.
17043019 - Identification of risk factors in atypical chronic myeloid leukemia.
367569 - Acute ("malignant") myelosclerosis.
18792099 - Survival of peritoneal malignant mesothelioma in italy: a population-based study.
11812439 - Optic disk drusen, peripapillary choroidal neovascularization, and poems syndrome.
12494359 - Treatment of chiari malformation, syringomyelia and hydrocephalus by neuroendoscopic th...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Leukemia     Volume:  12     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-19     Completed Date:  1998-08-19     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1171-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Nagoya University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antineoplastic Agents, Phytogenic / adverse effects*
Base Sequence
Child
Child, Preschool
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Etoposide / adverse effects*
Female
Humans
Infant
Leukemia, Promyelocytic, Acute / etiology*,  genetics
Male
Middle Aged
Molecular Sequence Data
Neoplasm Proteins / genetics*
Neoplasms, Second Primary* / genetics
Oncogene Proteins, Fusion / genetics*
Topoisomerase II Inhibitors
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion; 0/Topoisomerase II Inhibitors; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; 33419-42-0/Etoposide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Compartmentalization of calcium extrusion mechanisms in the outer and inner segments of photorecepto...
Next Document:  Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic...