Document Detail

Etoposide-related acute promyelocytic leukemia.
MedLine Citation:
PMID:  9697869     Owner:  NLM     Status:  MEDLINE    
The development of therapy-related acute myeloid leukemia (t-AML) has become a growing concern over the past decade, because of the increase in the percentage of long-term survivors of primary malignancy. We reviewed 17 cases with etoposide-related acute promyelocytic leukemia (APL) reported in the literature. The close association between treatment with etoposide for Langerhans cell histiocytosis (LCH) and the development of etoposide-related APL was demonstrated among Japanese and Italians. Our data on the breakpoints (b/ps) of the PML and RARalpha genes are presented. It is suggested that chromatin structure might be more important than specific consensus sequence in the distribution of b/ps in etoposide-related APL.
K Kudo; H Yoshida; H Kiyoi; S Numata; K Horibe; T Naoe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Leukemia     Volume:  12     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-19     Completed Date:  1998-08-19     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1171-5     Citation Subset:  IM    
Department of Pediatrics, Nagoya University School of Medicine, Japan.
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MeSH Terms
Antineoplastic Agents, Phytogenic / adverse effects*
Base Sequence
Child, Preschool
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Etoposide / adverse effects*
Leukemia, Promyelocytic, Acute / etiology*,  genetics
Middle Aged
Molecular Sequence Data
Neoplasm Proteins / genetics*
Neoplasms, Second Primary* / genetics
Oncogene Proteins, Fusion / genetics*
Topoisomerase II Inhibitors
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion; 0/Topoisomerase II Inhibitors; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; 33419-42-0/Etoposide

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