| Etoposide-related acute promyelocytic leukemia. | |
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MedLine Citation:
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PMID: 9697869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of therapy-related acute myeloid leukemia (t-AML) has become a growing concern over the past decade, because of the increase in the percentage of long-term survivors of primary malignancy. We reviewed 17 cases with etoposide-related acute promyelocytic leukemia (APL) reported in the literature. The close association between treatment with etoposide for Langerhans cell histiocytosis (LCH) and the development of etoposide-related APL was demonstrated among Japanese and Italians. Our data on the breakpoints (b/ps) of the PML and RARalpha genes are presented. It is suggested that chromatin structure might be more important than specific consensus sequence in the distribution of b/ps in etoposide-related APL. |
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Authors:
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K Kudo; H Yoshida; H Kiyoi; S Numata; K Horibe; T Naoe |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Leukemia Volume: 12 ISSN: 0887-6924 ISO Abbreviation: Leukemia Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-19 Completed Date: 1998-08-19 Revised Date: 2013-03-04 |
Medline Journal Info:
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Nlm Unique ID: 8704895 Medline TA: Leukemia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1171-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Nagoya University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents, Phytogenic / adverse effects* Base Sequence Child Child, Preschool Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 17 Etoposide / adverse effects* Female Humans Infant Leukemia, Promyelocytic, Acute / etiology*, genetics Male Middle Aged Molecular Sequence Data Neoplasm Proteins / genetics* Neoplasms, Second Primary* / genetics Oncogene Proteins, Fusion / genetics* Topoisomerase II Inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion; 0/Topoisomerase II Inhibitors; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; 33419-42-0/Etoposide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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