| Etoposide in combination with cytarabine, doxorubicin, and 6-thioguanine for treatment of acute nonlymphoblastic leukemia in a protocol adjusted for age. | |
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MedLine Citation:
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PMID: 3802115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Etoposide combined with cytarabine, doxorubicin, and 6-thioguanine was used to treat 34 patients with acute nonlymphoblastic leukemia (ANLL) in an age-adjusted protocol, with patients greater than 50 years old receiving fewer days of therapy. Complete remissions (CR) occurred in 85% of all patients (29 of 34 patients). Patients less than or equal to 50 years of age achieved a 94% CR rate (17 of 18 patients) compared to a 75% CR rate (12 of 16 patients) in older patients. Duration of remission was less for those greater than 50 years of age. The remission rate for primary ANLL was 86% (19 of 22 patients) and for secondary or relapsed ANLL was 83% (ten of 12 patients). Thus, this is effective therapy for primary and secondary or relapsed ANLL. When the days of therapy are reduced for older patients' age, the remissions are fewer and less durable. |
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Authors:
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M M Bern; S R Wallach; C F Arkin; J J Lokich; M S Huberman; N R Anderson; J C Corkery; S D Paul; D F Phillips; H A Sonneborn |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer treatment reports Volume: 71 ISSN: 0361-5960 ISO Abbreviation: Cancer Treat Rep Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-13 Completed Date: 1987-03-13 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 7607107 Medline TA: Cancer Treat Rep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 201-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Age Factors Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Blood Cell Count Bone Marrow / pathology Cytarabine / administration & dosage Doxorubicin / administration & dosage Drug Administration Schedule Etoposide / administration & dosage Female Humans Leukemia / drug therapy*, mortality, pathology Male Middle Aged Thioguanine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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147-94-4/Cytarabine; 154-42-7/Thioguanine; 23214-92-8/Doxorubicin; 33419-42-0/Etoposide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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