Document Detail

Etoposide (VP-16) containing combination chemotherapy for treatment of patients with small cell lung cancer.
MedLine Citation:
PMID:  16892733     Owner:  NLM     Status:  MEDLINE    
A combination chemotherapy consisting of VP-16, vincristine, cyclophosphamide and CCNU was used to treat 24 patients of small cell lung cancer (extensive stage disease - 15 and limited stage - 9). In addition, radiotherapy of 1000 to 4000 cGys was given to primary disease in chest in 16 patients. The overall response rate was 95.8% with complete response (CR) in 9 (37.5%) and partial (PR) in 14 (58.3%) cases. The overall median survival was 24 weeks. In patients with CR, it was 39 weeks and in those with PR this was 22.5 weeks. The lone non-responder survived for only 8 weeks. The drugs were well tolerated.
D Behera; S K Jindal; S C Sharma
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Indian journal of chest diseases & allied sciences     Volume:  37     ISSN:  0377-9343     ISO Abbreviation:  Indian J Chest Dis Allied Sci     Publication Date:    1995 Jan-Mar
Date Detail:
Created Date:  2006-08-08     Completed Date:  2006-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7612044     Medline TA:  Indian J Chest Dis Allied Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.
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MeSH Terms
Antineoplastic Agents, Alkylating / administration & dosage
Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Small Cell / drug therapy*,  mortality,  pathology
Cyclophosphamide / administration & dosage
Etoposide / administration & dosage
Follow-Up Studies
Lomustine / administration & dosage
Lung Neoplasms / drug therapy*,  mortality,  pathology
Middle Aged
Survival Rate
Treatment Outcome
Vincristine / administration & dosage
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 0/Antineoplastic Agents, Phytogenic; 13010-47-4/Lomustine; 33419-42-0/Etoposide; 50-18-0/Cyclophosphamide; 57-22-7/Vincristine

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