| Etoposide (VP-16) containing combination chemotherapy for treatment of patients with small cell lung cancer. | |
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MedLine Citation:
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PMID: 16892733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A combination chemotherapy consisting of VP-16, vincristine, cyclophosphamide and CCNU was used to treat 24 patients of small cell lung cancer (extensive stage disease - 15 and limited stage - 9). In addition, radiotherapy of 1000 to 4000 cGys was given to primary disease in chest in 16 patients. The overall response rate was 95.8% with complete response (CR) in 9 (37.5%) and partial (PR) in 14 (58.3%) cases. The overall median survival was 24 weeks. In patients with CR, it was 39 weeks and in those with PR this was 22.5 weeks. The lone non-responder survived for only 8 weeks. The drugs were well tolerated. |
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Authors:
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D Behera; S K Jindal; S C Sharma |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Indian journal of chest diseases & allied sciences Volume: 37 ISSN: 0377-9343 ISO Abbreviation: Indian J Chest Dis Allied Sci Publication Date: 1995 Jan-Mar |
Date Detail:
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Created Date: 2006-08-08 Completed Date: 2006-08-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7612044 Medline TA: Indian J Chest Dis Allied Sci Country: India |
Other Details:
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Languages: eng Pagination: 15-9 Citation Subset: IM |
Affiliation:
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Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents, Alkylating / administration & dosage Antineoplastic Agents, Phytogenic / administration & dosage Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Carcinoma, Small Cell / drug therapy*, mortality, pathology Cyclophosphamide / administration & dosage Etoposide / administration & dosage Female Follow-Up Studies Humans Lomustine / administration & dosage Lung Neoplasms / drug therapy*, mortality, pathology Male Middle Aged Survival Rate Treatment Outcome Vincristine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Alkylating; 0/Antineoplastic Agents, Phytogenic; 13010-47-4/Lomustine; 33419-42-0/Etoposide; 50-18-0/Cyclophosphamide; 57-22-7/Vincristine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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