Document Detail


Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography.
MedLine Citation:
PMID:  11944589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Etizolam, an anti-anxiety agent which is an antagonist of platelet-activating factor receptors, was administered to patients with chronic subdural hematoma (CSH) after hematoma removal to assess the effectiveness for preventing recurrence compared with control patients not given the drug after surgery. The remaining volumes of subdural hematomas on brain computed tomography were measured approximately 1 month after removal. Volume in the etizolam group (15 patients) was significantly smaller than in the control group (24 patients). Hematoma recurrence was not detected in the etizolam group 3 months after surgery, but occurred in the control group. The difference was significant. Etizolam administration may be useful for the prevention of recurrence of CSH.
Authors:
Yutaka Hirashima; Naoya Kuwayama; Hideo Hamada; Nakamasa Hayashi; Shunro Endo
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  42     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-05-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  53-5; discussion 56     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Toyama. yhira@ms.toyama-mpu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Anxiety Agents / administration & dosage*
Diazepam / administration & dosage*,  analogs & derivatives*
Female
Follow-Up Studies
Hematoma, Subdural, Chronic / prevention & control,  radiography,  surgery*
Humans
Male
Middle Aged
Postoperative Complications / prevention & control*
Recurrence
Tomography, X-Ray Computed*
Treatment Outcome
Trephining
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 40054-69-1/etizolam; 439-14-5/Diazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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