Document Detail

Etiology of ventricular septal defects: an epidemiologic approach.
MedLine Citation:
PMID:  3840586     Owner:  NLM     Status:  MEDLINE    
To investigate the recent 150% increase in the reported incidence of ventricular septal defects (VSDs) in the United States, the epidemiology of ventricular septal defects was examined. The apparent incidence of VSDs is highly dependent on case finding methods, and more complete diagnosis and reporting probably account for the increase in reported incidence. Variations in case ascertainment also account for the small differences in incidence in studies from different places. The several known risk factors for VSD, including a family history of congenital heart disease and exposure to certain drugs, infectious agents, and maternal metabolic disturbances, explain few cases. Incidence rates are similar in different races and seasons and are unrelated to maternal age, birth order, sex, and socioeconomic status. VSDs occur naturally in a wide range of mammals and in birds, which also have four-chambered hearts. Despite identical genes and similar prenatal environments, the concordance rate in identical twins is only about 10%. The consistency of incidence among individuals with widely differing genes and environments and the frequency of discordance in identical twins suggest that VSDs often occur as random errors in development, at a frequency largely determined by the complexity of normal cardiac morphogenesis. This hypothesis has two major implications: many VSDs are not preventable and parents need not feel responsible for VSDs in their children.
T B Newman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  76     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-25     Completed Date:  1985-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  741-9     Citation Subset:  AIM; IM    
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MeSH Terms
Diseases in Twins
Epidemiologic Methods
Genetic Counseling
Heart Septal Defects / epidemiology,  etiology*,  genetics
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases / epidemiology
Prenatal Exposure Delayed Effects
Twins, Monozygotic
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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