Document Detail

Etiology of third-trimester maternal hyperuricemia in nonpreeclamptic twin gestations.
MedLine Citation:
PMID:  11152909     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether the higher maternal serum uric acid levels observed in the third trimester of nonpreeclamptic twin gestations result from increased uric acid production or decreased renal excretion. METHODS: Thirty-four nonpreeclamptic subjects with twin gestations were analyzed, along with 34 singleton controls matched for age, ethnicity, prepregnancy weight, height, and gestational age. For each subject, a serum sample and 24-hour urine specimen were obtained in the third trimester. Serum and urine uric acid and creatinine levels were determined, as well as total 24-hour urine uric acid, uric acid clearance, creatinine clearance, fractional uric acid clearance, and net tubular uric acid absorption. RESULTS: The twin gestation group had significantly higher maternal serum uric acid levels (5.2 +/- 1.2 compared with 4.0 +/- 1.0 mg/dL, P <.001) and maternal serum creatinine levels (0.7 +/- 0.2 compared with 0.5 +/- 0.1 mg/dL, P <.001) than the paired singleton group. This was associated with greater 24-hour urine uric acid excretion (688.7 +/- 167.0 compared with 597.7 +/- 164.2 mg, P =.04) and 24-hour urine creatinine excretion (1268.4 +/- 249.9 compared with 1161.2 +/- 277.1 mg, P =.03) in the twin group. No differences were seen between the groups in uric acid clearance, creatinine clearance, fractional uric acid clearance, filtered uric acid load, or net uric acid absorption. CONCLUSION: The higher maternal serum uric acid levels observed in the third trimester of nonpreeclamptic twin gestations result in part from increased uric acid production, as reflected in the increased daily uric acid excretion.
R L Fischer; L S Weisberg; M L Hediger
Related Documents :
8839679 - The effect of ipriflavone and its main metabolites on theophylline biotransformation.
18468199 - Relationship between serum uric acid levels and urinary albumin excretion in patients w...
18963429 - Titrimetric microdetermination of uric acid and thioglycollic acid by amplification rea...
15301519 - Multilayer assembly of prussian blue nanoclusters and enzyme-immobilized poly(toluidine...
3806829 - 2,8-dihydroxyadenine urolithiasis: report of an adult case in the united states.
1619189 - Changes in serum and urinary uric acid levels in normal human subjects fed purine-rich ...
14963199 - Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review.
23094139 - Artificial specific binders directly recovered from chemically modified nucleic acid li...
20161329 - Thio-mediated two-component coupling reaction of carboxylic acids and isonitriles under...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  97     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-02-22     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Cooper Hospital/University Medical Center, Camden, New Jersey 08103, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Pregnancy Complications / physiopathology*
Pregnancy Trimester, Third
Pregnancy, Multiple / physiology*
Prospective Studies
Uric Acid / blood*
Reg. No./Substance:
69-93-2/Uric Acid
Comment In:
Obstet Gynecol. 2001 Apr;97(4):641-2   [PMID:  11294176 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chronic maternal smoking and cord blood amino acid and enzyme levels at term.
Next Document:  Osteogenesis imperfecta: mode of delivery and neonatal outcome.