Document Detail

Etiology of surface light scattering on hydrophobic acrylic intraocular lenses.
MedLine Citation:
PMID:  22999603     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: To study the etiology of surface light scattering on hydrophobic acrylic intraocular lenses (IOLs).
SETTING: Alcon Research Laboratories, Fort Worth, Texas, USA.
DESIGN: Experimental study.
METHODS: Intraocular lenses were obtained from clinical explantations (n = 5), from human cadavers (n = 8), and from finished-goods inventory (controls). Surface light scattering was measured and imaged with the IOLs in various hydration states (dry, short-term wetted, and long-term hydrated) before and after proteins were quantified and removed. Selected IOL samples were analyzed with x-ray photoelectron spectroscopy, scanning electron microscopy (SEM) with energy-dispersion x-ray analysis, Fourier-transform infrared spectroscopy with attenuated total reflectance, and cryogenic SEM with a focused ion beam.
RESULTS: No inorganic deposits or organic changes were observed on any IOL surface. Under clinically relevant hydrated conditions, surface light-scattering intensity was independent of proteinaceous biofilm state (P≥.11). Instead, the hydration state of the IOLs significantly contributed to the intensity of surface light scattering (P<.001); clinically explanted and cadaver-eye IOLs (but not control IOLs) exhibited minimal scatter when dry, intermediate scatter when wetted, and maximum scatter when hydrated. Subsurface nanoglistenings with diameters less than a micron and with locations up to 120 μm from the surface of the IOLs were characterized by SEM with a focused ion beam and were identified as the source of the hydration-related surface light scattering.
CONCLUSION: Surface light scattering on hydrophobic IOLs was predominantly caused by hydration-related subsurface nanoglistenings within the acrylic IOL material.
FINANCIAL DISCLOSURE: The authors are employees of Alcon Research, Ltd.
Marcia D Ong; Thomas A Callaghan; Ron Pei; Mutlu Karakelle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  38     ISSN:  1873-4502     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1833-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
From Alcon Research, Ltd., Fort Worth, Texas, USA. Electronic address:
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