Document Detail

Etiology-specific outcomes of intracytoplasmic sperm injection in azoospermic patients.
MedLine Citation:
PMID:  15749488     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess fertilization, pregnancy, and miscarriage rates after intracytoplasmic sperm injection (ICSI) with epididymal or testicular spermatozoa from different types of azoospermia. DESIGN: Retrospective study. SETTING: Academic medical center and private fertility center. PATIENT(S): Two hundred twelve patients underwent 257 ICSI cycles. INTERVENTION(S): Cycles of ICSI were divided into four groups according to the etiology of azoospermia: A (nonobstruction), B (postvasectomy), C (congenital obstruction), and D (obstruction due to infection). Testicular sperm aspiration and percutaneous epididymal sperm aspiration were the sperm retrieval methods used for ICSI. MAIN OUTCOME MEASURE(S): Fertilization, pregnancy, and miscarriage rates. RESULT(S): Normal fertilization rates were higher in groups C (67.7%) and B (64.1%) compared with groups A (47.3%) and D (58.9%). Although lower pregnancy rates were seen in group A, no statistical differences were detected among groups. However, the miscarriage rate was higher in group A (45.6%) compared with groups B (25.25%), C (24%), and D (22.58%). CONCLUSION(S): Although no differences were detected in the pregnancy rates across groups, fertilization and implantation rates were higher in patients with congenital obstruction of the seminal path. The pregnancy rate was higher and the miscarriage rate lower when epididymal sperm was used compared with testicular sperm.
Fábio F Pasqualotto; Lia Mara Rossi; Patrícia Guilherme; Valdemar Ortiz; Assumpto Iaconelli; Edson Borges
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  83     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  606-11     Citation Subset:  IM    
Fertility--Center for Assisted Reproduction, São Paulo, SP, Brazil.
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MeSH Terms
Abortion, Spontaneous
Epididymis / cytology
Infection / complications
Oligospermia / etiology*,  pathology,  therapy*
Pregnancy Rate*
Retrospective Studies
Sperm Injections, Intracytoplasmic*
Testis / cytology
Treatment Outcome
Comment In:
Fertil Steril. 2005 Jul;84(1):266-7; author reply 267-8   [PMID:  16009207 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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