| Etiology of the pulmonary pathophysiology associated with inhalation injury. | |
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MedLine Citation:
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PMID: 3024279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study describes an experimental model of smoke inhalation injury in sheep in which the same pathophysiologic alterations occur as with clinical inhalation injury in man. Diffuse pulmonary mucosal sloughing with atelectasis and emphysema with concomitant development of pulmonary edema results in a decrease in arterial oxygen and progressive pulmonary deterioration which results in a substantial mortality. Increased pulmonary edema fluid is shown to be caused by an increased microvascular permeability to protein with pulmonary lymph and tracheobronchial fluid, a filtrate of plasma. Concomitant with this increase in microvascular permeability is an influx of neutrophils, release of proteolytic enzymes and an identified presence of the metabolite of the prostanoid thromboxane A2 which are postulated as contributors to the progressive pulmonary dysfunction post inhalation injury. |
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Authors:
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D N Herndon; L D Traber; H Linares; J D Flynn; G Niehaus; G Kramer; D L Traber |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Resuscitation Volume: 14 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1987-01-06 Completed Date: 1987-01-06 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: IRELAND |
Other Details:
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Languages: eng Pagination: 43-59 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Burns, Inhalation / complications, physiopathology* Capillary Permeability Extracellular Space / metabolism Female Lung / physiopathology* Lymph / secretion Neutrophils / metabolism Peptide Hydrolases / metabolism Pulmonary Atelectasis / etiology Pulmonary Edema / etiology Sheep Thromboxane A2 / metabolism |
| Chemical | |
Reg. No./Substance:
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57576-52-0/Thromboxane A2; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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