Document Detail

Etiology of pneumonia, sepsis and meningitis in infants younger than three months of age in Ethiopia.
MedLine Citation:
PMID:  10530575     Owner:  NLM     Status:  MEDLINE    
METHODS: Within a multicenter study coordinated by WHO, an investigation of the etiologic agents of pneumonia, sepsis and meningitis was performed among infants younger than 3 months of age seen at the Ethio-Swedish Children's Hospital in Addis Ababa for a period of 2 years. Of the 816 infants enrolled 405 had clinical indications for investigation.
RESULTS: There were a total of 41 isolates from blood cultures from 40 infants. The study showed that the traditionally known acute respiratory infection pathogen Streptococcus pneumoniae was most common in this extended neonatal age group, found in 10 of 41 blood isolates. Streptococcus pyogenes was a common pathogen in this setting (9 of 41 blood isolates), whereas Salmonella group B was found in 5 of 41 isolates. Streptococcus agalactiae, which is a common pathogen in developed countries, was absent. A study of the susceptibility pattern of these organisms suggests that a combination of ampicillin with an aminoglycoside is adequate for initial treatment of these serious bacterial infections, but the combination is not optimal for the treatment of Salmonella infections. Among 202 infants on whom immunofluorescent antibody studies for viruses were performed based on nasopharyngeal aspirates, respiratory syncytial virus was found in 57 (28%) infants, and Chlamydia trachomatis was isolated in 32 (15.8%) of 203 infants.
L Muhe; M Tilahun; S Lulseged; S Kebede; D Enaro; S Ringertz; G Kronvall; S Gove; E K Mulholland
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  18     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-18     Completed Date:  1999-11-18     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S56-61     Citation Subset:  IM    
Department of Paediatrics and Child Health, Faculty of Medicine, Addis Ababa University, Ethiopia.
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MeSH Terms
Bacteria / drug effects,  isolation & purification
Bacterial Infections / diagnosis*,  epidemiology*
Blood / microbiology
Cerebrospinal Fluid / microbiology
Developing Countries*
Drug Resistance, Microbial
Ethiopia / epidemiology
Infant, Newborn
Meningitis / epidemiology,  etiology*
Microbial Sensitivity Tests
Pneumonia / epidemiology,  etiology*
Sepsis / epidemiology,  etiology*
Virus Diseases / diagnosis*,  epidemiology*
Viruses / drug effects,  isolation & purification
World Health Organization

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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