Document Detail

Etiology, pathogenesis and management of thoracic aortic aneurysm.
MedLine Citation:
PMID:  17653114     Owner:  NLM     Status:  MEDLINE    
Given the growing proportion of elderly people in Western societies and the increasing prevalence of chronic hypertension, the management of aneurysmal aortic disease is an ever growing challenge. Although degenerative changes in the aortic wall are common to thoracic aortic aneurysm (TAA) and to various types of dissection in general, TAA can result from specific heritable disorders of connective tissues. Today, increased awareness of vascular diseases and access to tomographic imaging equipment facilitate the diagnosis of TAA, even when asymptomatic. While most TAA cases with ascending aortic involvement are treated with surgical repair (primarily valve-preserving techniques), aneurysms of the distal arch and descending thoracic aorta are amenable to alternatives to classic open repair such as the emerging endovascular treatment techniques. In this Review, we provide a comprehensive overview of the etiology, pathophysiology and clinical management of patients with TAA, and discuss the most recent literature on the condition.
Hüseyin Ince; Christoph A Nienaber
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Cardiovascular medicine     Volume:  4     ISSN:  1743-4300     ISO Abbreviation:  -     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226507     Medline TA:  Nat Clin Pract Cardiovasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  418-27     Citation Subset:  IM    
Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Rostock, Germany.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Age Factors
Aortic Aneurysm, Thoracic / diagnosis,  etiology*,  genetics,  therapy*
Blood Vessel Prosthesis
Combined Modality Therapy
Risk Factors
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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