Document Detail


Etiology and outcome of cardioembolic stroke in young adults in Greece.
MedLine Citation:
PMID:  20378514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Cardioembolism is the most frequent cause of ischemic stroke in Greece. However, data regarding this stroke subtype in young adults from Greece and the East Mediterranean area are scarce.
METHODS: We aimed to determine the source of embolism and evaluate outcomes in a sample of young Greek patients with ischemic stroke of cardioembolic etiology. A series of 245 Greek patients with ischemic stroke at an age up to 45 years were selected from a consecutive series of 2820 first-ever stroke patients admitted to our departments during the period January 1998 to December 2008.
RESULTS: Cardioembolism was diagnosed in 45 cases (18.4%). Almost half of the cases (48.9%) were attributed to congenital anomalies of the interatrial septum, including 13 cases of patent foramen ovale (28.9%), 7 cases of atrial septum aneurysm (15.6%), and 1 case with both defects (2.2%). The majority of strokes in our young patient collective were related to medium-risk sources of embolism, while high-risk sources, namely dilated cardiomyopathy, atrial fibrillation and akinetic left ventricular lesions, were found in only 33.3%. The overall probability of 10-year survival was 89.4% (95% confidence interval 79.4-99.4), whereas the probability of a new composite vascular event was 14.3% (95% confidence interval 2.3-26.3) during the same period. The clinical outcome in general was excellent, since the majority of patients (82.2%) showed no significant handicap on follow up.
CONCLUSIONS: As in other western countries, it would seem that atrioseptal abnormalities played an important role as a cause of cardioembolism in this young Greek population, whereas atrial fibrillation and other major cardioembolic sources seem to be of minor relevance as compared to stroke in elderly patients.
Authors:
Konstantinos Spengos; Konstantinos N Vemmos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hellenic journal of cardiology : HJC = Hellēnikē kardiologikē epitheōrēsē     Volume:  51     ISSN:  2241-5955     ISO Abbreviation:  Hellenic J Cardiol     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-12-14     Revised Date:  2013-08-07    
Medline Journal Info:
Nlm Unique ID:  101257381     Medline TA:  Hellenic J Cardiol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Athens School of Medicine, Eginition Hospital, Athens, Greece. Spengos@hol.gr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Echocardiography / methods
Electrocardiography / methods
Embolism / complications*
Female
Greece
Heart Diseases / complications*,  ultrasonography
Humans
Longitudinal Studies
Male
Middle Aged
Risk Factors
Stroke / etiology*
Survival Rate
Treatment Outcome
Young Adult

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