Document Detail


Etiology of nasal polyps in cystic fibrosis: not a unimodal disease.
MedLine Citation:
PMID:  23012896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The objective was to determine whether the polyp subtypes observed in cystic fibrosis (CF)-related sinusitis were similar to those observed in non-CF-related sinusitis.
METHODS: Polyp and mucus samples were collected from CF patients who presented for sinus surgery. The polyps underwent histologic and cytochemical evaluation for the presence of lymphocyte cell populations and their respective cytokine markers. The mucus samples were evaluated for DNA content.
RESULTS: Of the polyps, 42% had an eosinophilic infiltrate, of which 80% had an additional mixed neutrophilic infiltrate. Of the remaining polyp samples, 42% did not have a granulocytic infiltrate, consistent with non-eosinophilic polyps. All samples had CD138-positive plasma cells. The mucus samples from the patients with CF showed higher extracellular DNA concentrations than did the mucus samples from patients with non-CF sinus disease.
CONCLUSIONS: Cystic fibrosis-related polyps demonstrated an eosinophil-based dichotomy similar to that of idiopathic non-CF-related polyps. Many also demonstrated neutrophilic infiltrate, indicating that chronic mucus stasis and infection complicate the disease. Agents capable of reducing extracellular DNA may help manage sinusitis in CF patients.
Authors:
John W Steinke; Spencer C Payne; Philip G Chen; Julie Negri; Edward B Stelow; Larry Borish
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  121     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-27     Completed Date:  2012-10-25     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-86     Citation Subset:  AIM; IM    
Affiliation:
Asthma and Allergic Disease Center, Carter Immunology Center, Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia, USA.
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MeSH Terms
Descriptor/Qualifier:
Cystic Fibrosis / complications*,  immunology,  metabolism
Eosinophils / metabolism
Flow Cytometry
Humans
Immunohistochemistry
Inflammation Mediators / analysis
Nasal Polyps / complications,  etiology*,  metabolism
Neutrophils / metabolism
Sinusitis / complications,  metabolism
Syndecan-1 / metabolism
Grant Support
ID/Acronym/Agency:
AI057483/AI/NIAID NIH HHS; AI070364/AI/NIAID NIH HHS; AI090413/AI/NIAID NIH HHS; R01 AI057438/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators; 0/Syndecan-1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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