| Etiology of intellectual impairment in Duchenne muscular dystrophy. | |
| | |
MedLine Citation:
|
PMID: 2310438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The precise etiology of intellectual impairment in Duchenne muscular dystrophy (DMD) is unknown. Histopathologic and computed tomographic studies have revealed structural brain changes; however, to our knowledge, no cranial magnetic resonance imaging (MRI) studies have been performed on DMD patients to further delineate these structural changes. We prospectively studied 4 DMD patients by cranial MRI, DNA deletion analysis, clinical evaluation, and intelligence testing. There was no significant correlation between verbal intelligence scores and MRI findings, DNA deletion, or the clinical severity of the disease. These first MRI studies of DMD did not reveal any significant anatomic brain alteration, other than mild atrophy in 2 patients. We believe these results must be considered when investigating the etiology of intellectual impairment in DMD in future studies with larger patient samples. |
| | |
Authors:
|
A A al-Qudah; J Kobayashi; S Chuang; M Dennis; P Ray |
Related Documents
:
|
17362998 - Does perfusion ct enable differentiating alzheimer's disease from vascular dementia and... 16306398 - Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pa... 16411968 - White matter hyperintensities and cortical acetylcholinesterase activity in parkinsonia... 3118678 - Ct in progressive supranuclear palsy. 15642288 - Electrocardiographic assistance in multidetector ct of thoracic disorders. 21231108 - Direct measurement of effective magnetic diffusivity in turbulent flow of liquid sodium. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatric neurology Volume: 6 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1990 Jan-Feb |
Date Detail:
|
Created Date: 1990-04-25 Completed Date: 1990-04-25 Revised Date: 2006-05-23 |
Medline Journal Info:
|
Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 57-9 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Jordan University Hospital, Amman. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Brain / pathology Cognition Disorders / diagnosis, etiology* Humans Intelligence Tests Magnetic Resonance Imaging* Male Muscular Dystrophies / complications*, genetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Megalencephaly secondary to occlusion and stenosis of sigmoid sinuses.
Next Document: Brain death secondary to arteriovenous hemangioma of the forearm.