Document Detail

Etiology of diarrhea in older children, adolescents and adults: a systematic review.
MedLine Citation:
PMID:  20689809     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Diarrhea is an important cause of morbidity and mortality in all regions of the world and among all ages, yet little is known about the fraction of diarrhea episodes and deaths due to each pathogen.
METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic literature review to identify all papers reporting the proportion of diarrhea episodes with positive laboratory tests for at least one pathogen in inpatient, outpatient and community settings that met our inclusion and exclusion criteria. We identified a total of 25,701 papers with possible etiology data and after final screening included 22 papers that met all inclusion and exclusion criteria. Enterotoxigenic Escherichia coli and V. cholerae O1/O139 were the leading causes of hospitalizations. In outpatient settings, Salmonella spp., Shigella spp., and E. histolytica were the most frequently isolated pathogens.
CONCLUSIONS/SIGNIFICANCE: This is the first systematic review which has considered the relative importance of multiple diarrhea pathogens. The few studies identified suggest that there is a great need for additional prospective studies around the world in these age groups to better understand the burden of disease and the variation by region.
Christa L Fischer Walker; David Sack; Robert E Black
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-03
Journal Detail:
Title:  PLoS neglected tropical diseases     Volume:  4     ISSN:  1935-2735     ISO Abbreviation:  PLoS Negl Trop Dis     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-11-12     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101291488     Medline TA:  PLoS Negl Trop Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e768     Citation Subset:  IM    
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
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MeSH Terms
Bacteria / classification,  isolation & purification
Bacterial Infections / epidemiology*,  microbiology*
Child, Preschool
Diarrhea / epidemiology*,  etiology*
Eukaryota / classification,  isolation & purification
Hospitalization / statistics & numerical data
Protozoan Infections / epidemiology*,  parasitology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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