Document Detail

Etiology of Paget's disease of bone
MedLine Citation:
PMID:  1108161     Owner:  NLM     Status:  MEDLINE    
The etiology of Paget's disease is just as doubtful in 1975 as it was in 1876 when Sir James Paget described the disease. The authors analyse the etiology on the basis of 100 personal cases and the literature. Although there are undoubtedly familial cases of the disease, investigation of the leucocyte grouping of 46 patients with Paget's disease did not reveal any correlation between occurrence of the disease and the HL-A antigens. Various pathological associations have been reported in the literature and were also found in this series. These associations were at the limits of coincidence (inflammatory rheumatism, diffuse chondrocalcinosis, multiple myeloma...). Metabolic changes (hyperuricaemia, hyperglycaemia, dyslipidaemia) did not appear to be more frequent than in control patients. Involvement of elastic tissue and the presence of pseudocrystalline inclusions in the osteoclasts constitute interesting points for discussion.
L Simon; F Blotman; J Seignalet; J Claustre
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Revue du rhumatisme et des maladies ostéo-articulaires     Volume:  42     ISSN:  0035-2659     ISO Abbreviation:  Rev Rhum Mal Osteoartic     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0407211     Medline TA:  Rev Rhum Mal Osteoartic     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  535-44     Citation Subset:  IM    
Vernacular Title:
Etiologie de la maladie osseuse de Paget
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MeSH Terms
Calcinosis / complications
Chondrocalcinosis / complications
Diabetes Complications
Gout / complications
HLA Antigens
Hyperlipidemias / complications
Middle Aged
Multiple Myeloma / complications
Osteitis Deformans / epidemiology,  etiology*,  genetics
Pseudoxanthoma Elasticum / complications
Vascular Diseases / complications
Reg. No./Substance:
0/HLA Antigens

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