Document Detail


Etiology of insulin resistance in youth with type 2 diabetes.
MedLine Citation:
PMID:  23135953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Type 2 diabetes (T2DM), historically an adult disease, is now increasingly prevalent in obese youth. Poor diet and increased sedentary behavior contribute to the increasing rates of obesity in youth, yet not all obese children develop T2DM. In general, T2DM is characterized by both insulin resistance (IR) and pancreatic beta-cell insufficiency. In children, IR is related to elevated body mass index (BMI) and pubertal hormones, along with abnormal fat partitioning, elevated free fatty acids, inflammation, and/or mitochondrial dysfunction. Hyperglycemia and T2DM develop when the pancreas cannot match the increased insulin demands resulting from IR. Unique to youth, IR varies with stage of pubertal development, and some children may have resolution of hyperglycemia post-puberty once the IR of puberty resolves. Further understanding of IR, the progression to T2DM in youth, and later outcomes as adults will help direct future therapies and interventions for youth at risk.
Authors:
Melanie Cree-Green; Taylor M Triolo; Kristen J Nadeau
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current diabetes reports     Volume:  13     ISSN:  1539-0829     ISO Abbreviation:  Curr. Diab. Rep.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-06-19     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101093791     Medline TA:  Curr Diab Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children's Hospital Colorado, Box # 265, 13123 E. Colfax Avenue, Aurora, CO 80045, USA. Melanie.Green@childrenscolorado.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Diabetes Mellitus, Type 2 / etiology*,  pathology,  physiopathology*
Disease Progression
Humans
Insulin Resistance*
Insulin-Secreting Cells / pathology
Life Style
Grant Support
ID/Acronym/Agency:
1R56DK088971-01/DK/NIDDK NIH HHS; P30 DK048520/DK/NIDDK NIH HHS; RR020038-05/RR/NCRR NIH HHS; T32 DK063687/DK/NIDDK NIH HHS

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