Document Detail


Etiologies of autism in a case-series from Tanzania.
MedLine Citation:
PMID:  16897390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most autism has a genetic cause although post-encephalitis cases are reported. In a case-series (N = 20) from Tanzania, 14 met research criteria for autism. Three (M:F = 1:2) had normal development to age 22, 35, and 42 months, with onset of autism upon recovery from severe malaria, attended by prolonged high fever, convulsions, and in one case prolonged loss of consciousness. In four other cases (M:F = 3:1), the temporal relationship between onset of autism and severe infection was close, but possibly spurious since malaria is common in Tanzania and there were indications of abnormal development in the child or a family member. In seven cases, (M:F = 6:1) autism onset was unrelated to malaria. The excess of non-verbal cases (N = 10) is related local diagnostic practice.
Authors:
Raymond E Mankoski; Martha Collins; Noah K Ndosi; Ella H Mgalla; Veronica V Sarwatt; Susan E Folstein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  36     ISSN:  0162-3257     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1039-51     Citation Subset:  IM    
Affiliation:
Tufts University School of Medicine and Sackler School of Graduate Biomedical Sciences, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Autistic Disorder / diagnosis*,  epidemiology,  etiology*
Case-Control Studies
Child
Child, Preschool
Female
Humans
Malaria / complications*,  epidemiology
Male
Nonverbal Communication
Severity of Illness Index
Stereotyped Behavior
Tanzania

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