Document Detail

Etiological factors for the persistence of endemic goiter in selected areas of Siddharthnagar district in Eastern Uttar Pradesh, India.
MedLine Citation:
PMID:  19554805     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the prevalence of goiter, state of iodine nutrition of the population, consumption pattern of common goitrogenic food, and distribution of iodine through edible salt in selected CD Blocks of Siddharthnagar district in Eastern Uttar Pradesh. METHODS: Goiter survey among 1,862 school children, aged 6-12 years, of both sexes, and analysis of iodine (I) and thiocyanate (SCN) in 240 urine samples, and iodine content in 210 edible salt samples collected from the selected study areas. RESULTS: The prevalence of goiter was 26.3% (grade 1: 23.2%; grade 2: 3.1%). Median urinary iodine level was 6.0 microg/dl, and 42% had concentration < 5 microg/dl. Mean (SD) urinary SCN was 0.75 (0.4) mg/dl. Only17.1% of salt samples had iodine level > 15 ppm; 82.9% had < 15 ppm. CONCLUSION: Consumption of inadequately iodized salt and cyanogenic plant foods containing goitrogenic/anti-thyroidal substances by the people of the studied region are possible reasons for the persistence of goiter during the post salt iodination phase.
A K Chandra; A Bhattacharjee; T Malik; S Ghosh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  22     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-25     Citation Subset:  IM    
Endocrinology and Reproductive Physiology Laboratory, Department of Physiology, University College of Science and Technology, University of Calcutta, West Bengal, India.
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MeSH Terms
Age Factors
Goiter, Endemic / epidemiology*
India / epidemiology
Iodine / administration & dosage,  deficiency*,  urine
Rural Population
Sex Factors
Sodium Chloride, Dietary / administration & dosage
Thiocyanates / urine
Urban Population
Reg. No./Substance:
0/Sodium Chloride, Dietary; 0/Thiocyanates; 0/iodized salt; 302-04-5/thiocyanate; 7553-56-2/Iodine

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