Document Detail

Etiological aspects on craniofacial morphology in twins with cleft lip and palate.
MedLine Citation:
PMID:  10232458     Owner:  NLM     Status:  MEDLINE    
The craniofacial morphology of 39 Finnish twin pairs concordant or discordant for cleft of the lip (CL), unilateral cleft lip and palate (UCLP), or cleft palate only (CP) was studied by means of lateral cephalometric radiographs. The intrapair differences between various cleft and twin subgroups were compared by means of univariate analysis; multivariable analysis of cleft discordant pairs and the variance components were estimated with the TWINAN program. Larger values for intrapair differences were found, especially in linear measurements in older twin pairs. Heritability estimates for the cranial base measurements and, to a lesser extent, for the mandibular measurements were high. Comparisons on the basis of cleft type revealed more differences between twin pairs when clefting was more severe. Concordant and discordant CP twin pairs showed similarity in their intrapair craniofacial morphology, indicating that surgery seemed to have no major effect on their craniofacial morphology. A similar comparison in discordant UCLP showed that, in addition to clefting itself, external factors, i.e., the repaired cleft's direct effects on craniofacial morphology, have a strong influence on craniofacial morphology, especially in the maxillas of the UCLP twins. The craniofacial morphology in these Finnish twins supports the hypothesis of different genetic behavior for cleft lip and cleft lip and palate (CL(P)) and CP in Finland.
T Laatikainen
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Publication Detail:
Type:  Comparative Study; Journal Article; Twin Study    
Journal Detail:
Title:  European journal of oral sciences     Volume:  107     ISSN:  0909-8836     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-03     Completed Date:  1999-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  D; IM    
Cleft Center, Department of Plastic Surgery, Helsinki University Central Hospital, Finland.
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MeSH Terms
Analysis of Variance
Child, Preschool
Cleft Lip / genetics*,  pathology
Cleft Palate / genetics*,  pathology
Diseases in Twins*
Facial Bones / anatomy & histology
Logistic Models
Maxillofacial Development*
Skull Base / anatomy & histology
Twins, Dizygotic
Twins, Monozygotic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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