Document Detail

Etiological agents of lower respiratory tract infections in Japanese children.
MedLine Citation:
PMID:  15011754     Owner:  NLM     Status:  MEDLINE    
To investigate the etiology of pediatric community-acquired pneumonia and bronchitis, we conducted a prospective, population-based study covering the total population < 15 years of age in 16 municipalities in Hokkaido, Japan, during the period of April 2000 to March 2001. Chest radiographs were available for all cases (n = 921; 398 as pneumonia and 523 as bronchitis) and paired sera for serologic assays were available for more than half of the cases. The following specimens were also collected: nasopharyngeal swabs for viral, bacteriological, mycoplasmal and chlamydial studies, blood for serology and blood culture. The children were then followed-up on days 3, 7 and 14. Specific infecting organisms were identified in a total of 853 (92.6%) out of 921 patients (398 cases of pneumonia and 523 cases of bronchitis) including 205 with mixed infection as follows: Mycoplasma pneumoniae, 252 (274%) patients; respiratory syncytial (RS) virus, 188 (20.4%); influenza A virus, 110 (11.9%); Streptococcus pneumoniae, 95 (10.3%); Haemophilus influenzae, 90 (9.8%); Haemophilus parainfluenzae, 35 (3.8%); Staphylococcus aureus, 29 (3.1%); adenovirus, 27 (2.9%); Moraxella catarrhalis, 12 (1.3%); Pseudomonas aeruginosa , 7 (0.8%); Chlamydia pneumoniae, 6 (0.7%); and other agents, 2 (0.2%). Mycoplasma infections were seen even in patients less than 5 years and RS and influenza A virus infections in patients more than 5 years of age. The importance of M. pneumoniae and RS virus in the etiology of lower respiratory infections in Japanese children was confirmed.
Kei Numazaki; Shunzo Chiba; Masao Umetsu; Toru Tanaka; Hideatsu Yoshimura; Yoshinori Kuniya; Junichi Miura; Noriaki Adachi; Susumu Ukae; Toshihiko Mori; Daisuke Ueda; Tomoyuki Hotsubo; Toshiya Sato
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  18     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-03-11     Completed Date:  2004-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Research Group of Hokkaido for Pediatric Respiratory Tract Infections, Department of Pediatrics, Sapporo Medical University School of Medicine, Japan.
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MeSH Terms
Bronchitis / epidemiology,  microbiology,  virology
Child, Preschool
Community-Acquired Infections / epidemiology,  microbiology*,  virology*
Follow-Up Studies
Japan / epidemiology
Pneumonia, Bacterial / epidemiology
Pneumonia, Viral / epidemiology
Prospective Studies
Respiratory Tract Infections / epidemiology,  microbiology*,  virology*

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