Document Detail

An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
MedLine Citation:
PMID:  21892413     Owner:  NLM     Status:  Publisher    
Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS). Kindling occurs when an organism is exposed repeatedly to an initially sub-threshold stimulus resulting in hypersensitivity and spontaneous seizure-like activity. Among patients with ME/CFS, chronically repeated low-intensity stimulation due to an infectious illness might cause kindling of the limbic-hypothalamic-pituitary axis. Kindling might also occur by high-intensity stimulation (e.g., brain trauma) of the limbic-hypothalamic-pituitary axis. Once this system is charged or kindled, it can sustain a high level of arousal with little or no external stimulus and eventually this could lead to hypocortisolism. Seizure activity may spread to adjacent structures of the limbic-hypothalamic-pituitary axis in the brain, which might be responsible for the varied symptoms that occur among patients with ME/CFS. In addition, kindling may also be responsible for high levels of oxidative stress, which has been found in patients with ME/CFS.
Leonard A Jason; Matthew Sorenson; Nicole Porter; Natalie Belkairous
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Publication Detail:
Journal Detail:
Title:  Neuroscience and medicine     Volume:  2     ISSN:  2158-2947     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-9-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101558459     Medline TA:  Neurosci Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  14-27     Citation Subset:  -    
DePaul University, Center for Community Research. Fullerton Ave., Chicago, USA.
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Grant Support
R01 AI036295-02S1//NIAID NIH HHS; R01 AI055735-01A2//NIAID NIH HHS

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