Document Detail

Etiologic factors and pathologic alterations in selenium-vitamin E deficiency and excess in animals and humans.
MedLine Citation:
PMID:  1379446     Owner:  NLM     Status:  MEDLINE    
The etiology of selenium-vitamin E (Se-E) deficiency diseases may be complex. Many of the syndromes involve combined deficiency of selenium and vitamin E. Selenium moves into the animal and human food chain from soil and plants, which may contain inadequate amounts of the nutrient in many areas of the world. Vitamin E may be in low concentration in many animal feeds unless supplements are added. Some syndromes, such as steatitis in cats, result from an increased requirement of vitamin E in diets that contain large amounts of polyunsaturated fatty acids, and these diseases will only respond to vitamin E administration. Deficiency syndromes in animals owing to pure Se deficiency are infrequent and have been produced mainly by laboratory studies utilizing extreme deficiency conditions. Other factors that may affect the occurrence of these deficiency diseases are concurrent dietary deficiency of S-containing amino acids, bioavailability of different forms of dietary Se, intake of compounds that antagonize Se (e.g., silver salts), and exposure to various prooxidant substances (e.g., iron compounds, oxygen, ozone, and various drugs).
J F Van Vleet; V J Ferrans
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biological trace element research     Volume:  33     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:    1992 Apr-Jun
Date Detail:
Created Date:  1992-09-04     Completed Date:  1992-09-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-21     Citation Subset:  IM    
Department of Pathobiology, School of Veterinary Medicine, Purdue University West Lafayette, IN 47907.
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MeSH Terms
Cardiomyopathies / etiology
Lipofuscin / metabolism
Muscles / pathology
Muscular Diseases / etiology
Myocardium / pathology
Nervous System Diseases / etiology
Selenium / adverse effects,  deficiency*,  toxicity
Vitamin E / adverse effects*,  toxicity
Vitamin E Deficiency* / etiology,  pathology
Reg. No./Substance:
0/Lipofuscin; 1406-18-4/Vitamin E; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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