| Etiologic factors and pathologic alterations in selenium-vitamin E deficiency and excess in animals and humans. | |
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MedLine Citation:
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PMID: 1379446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The etiology of selenium-vitamin E (Se-E) deficiency diseases may be complex. Many of the syndromes involve combined deficiency of selenium and vitamin E. Selenium moves into the animal and human food chain from soil and plants, which may contain inadequate amounts of the nutrient in many areas of the world. Vitamin E may be in low concentration in many animal feeds unless supplements are added. Some syndromes, such as steatitis in cats, result from an increased requirement of vitamin E in diets that contain large amounts of polyunsaturated fatty acids, and these diseases will only respond to vitamin E administration. Deficiency syndromes in animals owing to pure Se deficiency are infrequent and have been produced mainly by laboratory studies utilizing extreme deficiency conditions. Other factors that may affect the occurrence of these deficiency diseases are concurrent dietary deficiency of S-containing amino acids, bioavailability of different forms of dietary Se, intake of compounds that antagonize Se (e.g., silver salts), and exposure to various prooxidant substances (e.g., iron compounds, oxygen, ozone, and various drugs). |
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Authors:
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J F Van Vleet; V J Ferrans |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biological trace element research Volume: 33 ISSN: 0163-4984 ISO Abbreviation: Biol Trace Elem Res Publication Date: 1992 Apr-Jun |
Date Detail:
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Created Date: 1992-09-04 Completed Date: 1992-09-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-21 Citation Subset: IM |
Affiliation:
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Department of Pathobiology, School of Veterinary Medicine, Purdue University West Lafayette, IN 47907. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyopathies / etiology Humans Lipofuscin / metabolism Male Muscles / pathology Muscular Diseases / etiology Myocardium / pathology Nervous System Diseases / etiology Selenium / adverse effects, deficiency*, toxicity Vitamin E / adverse effects*, toxicity Vitamin E Deficiency* / etiology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Lipofuscin; 1406-18-4/Vitamin E; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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