Document Detail

Etiologic factors in rickets of very low-birth-weight infants.
MedLine Citation:
PMID:  7229765     Owner:  NLM     Status:  MEDLINE    
The incidence of rickets was found to be 32% (39/125) in a retrospective review of consecutive survivors of very low birth weight in whom serial radiographic and biochemical data were obtained. A higher proportion of these infants were black, had a greater initial weight loss, and had a longer hospitalization; there was a prevalence of births in the spring. Soy formula, supplemented with calcium and vitamin D but not phosphorus, was used predominantly in both groups; cumulative calcium, phosphorus, vitamin D, and caloric intakes were the same. We believe that the etiology of rickets in VLBW infants is multifactorial; however, nutritional deficiency is of central importance. Soy isolate formula, as well as human milk and many other commercially available formulas, do not provide sufficient calcium and phosphorus to keep pace with rates of intrauterine accretion. Supplementation with calcium, phosphorus, and vitamin D, beginning as soon as possible after birth, is indicated.
J C Callenbach; M B Sheehan; S J Abramson; R T Hall
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  98     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  800-5     Citation Subset:  AIM; IM    
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MeSH Terms
African Continental Ancestry Group
Calcium / therapeutic use
Food, Fortified / adverse effects
Infant Food / adverse effects
Infant, Low Birth Weight*
Infant, Newborn
Phosphorus / therapeutic use
Retrospective Studies
Rickets / etiology*,  prevention & control,  radiography
Vitamin D / therapeutic use
Reg. No./Substance:
1406-16-2/Vitamin D; 7440-70-2/Calcium; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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