| Etiologic evaluation of male pseudohermaphroditism in infancy and childhood. | |
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MedLine Citation:
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PMID: 6331153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We outlined a diagnostic scheme for use with prepubertal patients with male pseudohermaphroditism (MPH) that included karyotyping, a genitourethrogram, a human chorionic gonadotropin stimulation test with plasma hormone level determinations, and determination of 5 alpha-reductase activity and androgen receptor binding in genital skin fibroblasts. A thorough evaluation is warranted in all patients since the correct diagnosis may assist in determining gender assignment and providing appropriate genetic counseling. We studied 25 patients by the prescribed diagnostic scheme: seven of them had a partial gonadal dysgenesis, two were deficient in 5 alpha-reductase activity, two showed partial androgen insensitivity, four had multiple congenital malformations, one had a Wilms' tumor, and nine were considered as having an idiopathic form of MPH. |
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Authors:
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G D Berkovitz; P A Lee; T R Brown; C J Migeon |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 138 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-08-23 Completed Date: 1984-08-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 755-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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diagnosis Adolescent Biopsy Child Child, Preschool Chorionic Gonadotropin / blood Gonadal Dysgenesis / diagnosis Humans Infant Karyotyping Kidney Neoplasms / diagnosis Laparotomy Male Pseudohermaphroditism / diagnosis*, etiology Receptors, Androgen / metabolism Testosterone 5-alpha-Reductase / deficiency Wilms Tumor / diagnosis |
| Grant Support | |
ID/Acronym/Agency:
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5T32AM 07116/AM/NIADDK NIH HHS; AM 00180/AM/NIADDK NIH HHS; RR-00052/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Receptors, Androgen; EC 1.3.99.5/Testosterone 5-alpha-Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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