Document Detail

Etiologic aspects of chronic pancreatitis. Review of current theories and experimental evidence.
MedLine Citation:
PMID:  2702245     Owner:  NLM     Status:  MEDLINE    
The recent increase in incidence of chronic pancreatitis is difficult to explain. Alcohol consumption, although the prime precipitating factor, is not the only factor involved in the etiology. Differences in risk, presentation, and mortality in various areas of the world warrant investigation of the basic pathophysiologic mechanisms that are operative, and studies to determine if they are identical in all cases of chronic inflammatory diseases of the pancreas. Satisfactory animal models for human chronic pancreatitis have not yet been produced and it is still not known if the basic mechanism(s) leading to chronic pancreatitis are identical in all cases. The only theory concerning the etiopathogenesis of chronic pancreatitis that seems to have therapeutic merit involves the aberrant effects of mixed function oxidases, cytochrome P-450 induction, free radicals of oxygen, lipid peroxidation, and so on.
H Worning
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  5 Suppl     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-11-15     Completed Date:  1990-11-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
University of Copenhagen, Medical Department F, Glostrup Hospital, Denmark.
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MeSH Terms
Chronic Disease
Pancreas / pathology,  physiopathology
Pancreatitis / epidemiology,  etiology*,  mortality,  pathology
Risk Factors

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