| Etiologic aspects of chronic pancreatitis. Review of current theories and experimental evidence. | |
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MedLine Citation:
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PMID: 2702245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The recent increase in incidence of chronic pancreatitis is difficult to explain. Alcohol consumption, although the prime precipitating factor, is not the only factor involved in the etiology. Differences in risk, presentation, and mortality in various areas of the world warrant investigation of the basic pathophysiologic mechanisms that are operative, and studies to determine if they are identical in all cases of chronic inflammatory diseases of the pancreas. Satisfactory animal models for human chronic pancreatitis have not yet been produced and it is still not known if the basic mechanism(s) leading to chronic pancreatitis are identical in all cases. The only theory concerning the etiopathogenesis of chronic pancreatitis that seems to have therapeutic merit involves the aberrant effects of mixed function oxidases, cytochrome P-450 induction, free radicals of oxygen, lipid peroxidation, and so on. |
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Authors:
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H Worning |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of pancreatology : official journal of the International Association of Pancreatology Volume: 5 Suppl ISSN: 0169-4197 ISO Abbreviation: Int. J. Pancreatol. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-11-15 Completed Date: 1990-11-15 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8703511 Medline TA: Int J Pancreatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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University of Copenhagen, Medical Department F, Glostrup Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Denmark Humans Incidence Japan Minnesota Pancreas / pathology, physiopathology Pancreatitis / epidemiology, etiology*, mortality, pathology Risk Factors Switzerland |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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