Document Detail


Ethylene glycol poisoning.
MedLine Citation:
PMID:  16226155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethylene glycol (EG) can be found in many agents, such as antifreeze. Ingestion of EG may cause serious poisoning. Adults are typically exposed when EG is ingested as a cheap substitute for ethanol or in suicide-attempts. Children may be exposed by accidental ingestion caused by decantation of EG to unlabeled bottles. EG has in itself a low toxicity, but is in vivo broken down to four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid. The metabolites are cell toxins that cause central nervous system depression, and cardio-pulmonary and renal failure. Glycolic acid causes severe acidosis, and oxalate is precipitated as calcium oxalate in the kidneys and other tissues. We present five case reports of fatal EG-poisoning, and review the literature concerning clinical presentation and diagnosis, pathological findings, treatment and prevention.
Authors:
Peter Mygind Leth; Markil Gregersen
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2005-01-21
Journal Detail:
Title:  Forensic science international     Volume:  155     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Affiliation:
Institute of Forensic Medicine, University of Southern Denmark, Faculty of Health Sciences, Winsløvparken 17, DK-5000 Odense C, Denmark. pleth@health.sdu.dk
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MeSH Terms
Descriptor/Qualifier:
Acidosis / chemically induced
Adult
Brain / pathology
Calcium Oxalate / analysis
Ethylene Glycol / poisoning*
Forensic Pathology
Humans
Kidney Calculi / chemistry,  pathology
Liver / pathology
Lung / pathology
Male
Middle Aged
Seizures / chemically induced
Suicide
Chemical
Reg. No./Substance:
107-21-1/Ethylene Glycol; 25454-23-3/Calcium Oxalate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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