Document Detail

Ethylene glycol ingestion resulting in brainstem and midbrain dysfunction.
MedLine Citation:
PMID:  10930063     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Ethylene glycol toxicity has produced central nervous system abnormalities including coma, cerebral edema, and cranial nerve dysfunction.
CASE REPORT: A 26-year-old male developed widespread brainstem and midbrain dysfunction with corresponding cranial computed tomography findings after ingesting ethylene glycol. The computed tomography scan which was obtained 3 days after ethylene glycol ingestion showed low density areas in the basal ganglia, thalami, midbrain, and upper pons. The neurologic findings in our patient reflected dysfunction of all the areas of hypodensity on the cranial computed tomography scan. A magnetic resonance imaging of the brain obtained 24 days after ingestion revealed bilateral putamen necrosis. The patient's neurologic sequelae resolved over the following 4 months.
B W Morgan; M D Ford; R Follmer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  38     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  2000  
Date Detail:
Created Date:  2000-08-11     Completed Date:  2000-08-11     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  445-51     Citation Subset:  AIM; IM    
Emory University, Atlanta, Georgia, USA.
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MeSH Terms
Acute Kidney Injury / chemically induced,  therapy
Arrhythmias, Cardiac / chemically induced,  therapy
Brain Diseases / chemically induced*,  diagnosis,  therapy
Brain Edema / chemically induced
Brain Stem / drug effects*,  radiography
Calcium Gluconate / therapeutic use
Charcoal / therapeutic use
Coma / chemically induced
Cranial Nerve Diseases / chemically induced
Ethanol / therapeutic use
Ethylene Glycol / poisoning*
Mesencephalon / drug effects*,  radiography
Putamen / drug effects,  radiography
Pyridoxine / therapeutic use
Renal Dialysis
Sodium Bicarbonate / therapeutic use
Thiamine / therapeutic use
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
107-21-1/Ethylene Glycol; 144-55-8/Sodium Bicarbonate; 16291-96-6/Charcoal; 299-28-5/Calcium Gluconate; 59-43-8/Thiamine; 64-17-5/Ethanol; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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