| Ethyl propionate is more effective and less cytotoxic than methyl tert-butyl ether for topical gallstone dissolution. | |
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MedLine Citation:
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PMID: 9207283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Ethyl propionate and isopropyl acetate were identified as gallstone solvents with more favorable physicochemical properties than the currently used solvent methyl tert-butyl ether (MTBE). In this study, their efficacy and toxicity were compared. METHODS: To compare efficacy, matched stones from 33 patients were subjected to dissolution with each solvent. To evaluate cytotoxicity, jejunal segments of the anesthetized rat were exposed to each solvent or saline; the segments were then perfused with markers for active absorption and passive permeability. RESULTS: For 23 gallstone sets that dissolved completely with all three solvents, the average dissolution time was shorter with ethyl propionate (38 +/- 8 minutes) than with MTBE (60 +/- 13 minutes) (P = 0.03) or isopropyl acetate (55 +/- 12 minutes) (P < 0.001). Four stones did not dissolve with ethyl propionate, seven with MTBE, and eight with isopropyl acetate. After 2 minutes of exposure to the solvents, the dry weight of the segments decreased by 36% after MTBE but was unchanged after the other two solvents (P < 0.001). MTBE caused more inhibition of active absorption than the other solvents (P < 0.001) and a greater increase in passive permeation (P < 0.03). CONCLUSIONS: Ethyl propionate and isopropyl acetate are less toxic to the intestinal mucosa than MTBE, and ethyl propionate is more effective for gallstone dissolution. |
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Authors:
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S F Zakko; J C Scirica; M C Guttermuth; J Dodge; J J Hajjar |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 113 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-07-23 Completed Date: 1997-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 232-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Connecticut School of Medicine, Farmington 06030, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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therapeutic use*,
toxicity* Animals Cholelithiasis / therapy* Humans Intestinal Absorption / drug effects Intestinal Mucosa / drug effects* Jejunum / drug effects* Male Methyl Ethers / therapeutic use*, toxicity* Propionates / therapeutic use*, toxicity* Rats Rats, Sprague-Dawley Solvents / therapeutic use*, toxicity* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Methyl Ethers; 0/Propionates; 0/Solvents; 105-37-3/ethyl propionate; 108-21-4/isopropyl acetate; 1634-04-4/methyl tert-butyl ether |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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