Document Detail

Ethyl propionate is more effective and less cytotoxic than methyl tert-butyl ether for topical gallstone dissolution.
MedLine Citation:
PMID:  9207283     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Ethyl propionate and isopropyl acetate were identified as gallstone solvents with more favorable physicochemical properties than the currently used solvent methyl tert-butyl ether (MTBE). In this study, their efficacy and toxicity were compared. METHODS: To compare efficacy, matched stones from 33 patients were subjected to dissolution with each solvent. To evaluate cytotoxicity, jejunal segments of the anesthetized rat were exposed to each solvent or saline; the segments were then perfused with markers for active absorption and passive permeability. RESULTS: For 23 gallstone sets that dissolved completely with all three solvents, the average dissolution time was shorter with ethyl propionate (38 +/- 8 minutes) than with MTBE (60 +/- 13 minutes) (P = 0.03) or isopropyl acetate (55 +/- 12 minutes) (P < 0.001). Four stones did not dissolve with ethyl propionate, seven with MTBE, and eight with isopropyl acetate. After 2 minutes of exposure to the solvents, the dry weight of the segments decreased by 36% after MTBE but was unchanged after the other two solvents (P < 0.001). MTBE caused more inhibition of active absorption than the other solvents (P < 0.001) and a greater increase in passive permeation (P < 0.03). CONCLUSIONS: Ethyl propionate and isopropyl acetate are less toxic to the intestinal mucosa than MTBE, and ethyl propionate is more effective for gallstone dissolution.
S F Zakko; J C Scirica; M C Guttermuth; J Dodge; J J Hajjar
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  113     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-07-23     Completed Date:  1997-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-7     Citation Subset:  AIM; IM    
Department of Medicine, University of Connecticut School of Medicine, Farmington 06030, USA.
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MeSH Terms
Acetates / therapeutic use*,  toxicity*
Cholelithiasis / therapy*
Intestinal Absorption / drug effects
Intestinal Mucosa / drug effects*
Jejunum / drug effects*
Methyl Ethers / therapeutic use*,  toxicity*
Propionates / therapeutic use*,  toxicity*
Rats, Sprague-Dawley
Solvents / therapeutic use*,  toxicity*
Time Factors
Reg. No./Substance:
0/Acetates; 0/Methyl Ethers; 0/Propionates; 0/Solvents; 105-37-3/ethyl propionate; 108-21-4/isopropyl acetate; 1634-04-4/methyl tert-butyl ether

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