Document Detail


Ethosuximide in epileptic women during pregnancy and lactation period. Placental transfer, serum concentrations in nursed infants and clinical status.
MedLine Citation:
PMID:  6508976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 10 epileptic mothers treated with ethosuximide (ES) as well as their 13 newborns were included in this study. At birth foetal/maternal serum concentration ratios were 0.97 +/- 0.02 (n = 7) and ES half-lives in three neonates were 32, 37 and 38 h. The breast milk concentrations of ES were similar to those in maternal serum (milk/serum: 0.86 +/- 0.08, n = 12) and the nursed infants maintained serum levels between 15 and 40 micrograms/ml. Two major malformations (bilateral clefting, hare-lip) were observed in two neonates whose mothers received either ES/PB or ES/PMD comedication. The number of minor anomalies was higher in the ES group (6.2, n = 12) than in the pair-matched control group of infants born to non-epileptic mothers (2.1, n = 10). Neonatal behaviour complications occurred in seven infants, two of them were severely affected.
Authors:
W Kuhnz; S Koch; S Jakob; A Hartmann; H Helge; H Nau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  18     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-02-14     Completed Date:  1985-02-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  671-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology
Epilepsy / drug therapy*
Ethosuximide / adverse effects,  metabolism*
Female
Humans
Infant, Newborn
Lactation
Male
Maternal-Fetal Exchange*
Milk, Human / metabolism*
Placenta / metabolism*
Pregnancy
Pregnancy Complications / drug therapy*
Chemical
Reg. No./Substance:
77-67-8/Ethosuximide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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