| Ethosuximide: Liver enzyme induction and D-glucaric acid excretion. | |
| | |
MedLine Citation:
|
PMID: 22454956 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
1 A study has been carried out to determine if ethosuximide induces liver enzymes.2 Ethosuximide did not affect the urinary excretion of D-glucaric acid by healthy adult subjects nor was the mean daily D-glucaric acid excretion of three epileptic children on long term ethosuximide therapy different from that of three matched controls.3 Ethosuximide (10 mg/kg or 50 mg/kg daily) did not influence D-glucaric acid excretion or liver microsomal protein and cytochrome P450 contents of guinea pigs but at a dose of 100 mg/kg daily in rats it increased liver microsomal protein and cytochrome P450 without altering D-glucaric acid excretion.4 These results suggest that at anticonvulsant doses ethosuximide is unlikely to induce liver enzymes. The precise relationship between D-glucaric acid excretion and liver enzyme induction remains in doubt. |
| | |
Authors:
|
J C Gilbert; A K Scott; D B Galloway; J C Petrie |
Related Documents
:
|
8344756 - Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblast... 10407146 - Molecular docking studies on interaction of diverse retinol structures with human alcoh... 4736456 - Lysergic acid diethylamide: radioimmunoassay. 6577946 - Structure-activity relationships of a new series of retinoidal benzoic acid derivatives... 16104706 - Synthesis and structure of the bidimensional zeolite itq-32 with small and large pores. 22451526 - Amiloride-sensitive and amiloride-insensitive responses to nacl + acid mixtures in hams... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of clinical pharmacology Volume: 1 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1974 Jun |
Date Detail:
|
Created Date: 2012-03-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 249-52 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The persistence of adriamycin in man and rat.
Next Document: Urinary D-glucaric acid excretion and plasma antipyrine kinetics during enzyme induction.