| Ethnobotany, chemistry, and biological activities of the genus tithonia (asteraceae). | |
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MedLine Citation:
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PMID: 22344901 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The genus Tithonia is an important source of diverse natural products, particularly sesquiterpene lactones, diterpenes, and flavonoids. The collected information in this review attempts to summarize the recent developments in the ethnobotany, biological activities, and secondary metabolite chemistry of this genus. More than 100 structures of natural products from Tithonia are reported in this review. The species that has been most investigated in this genus is T. diversifolia, from which ca. 150 compounds were isolated. Biological studies are described to evaluate the anti-inflammatory, analgesic, antimalarial, antiviral, antidiabetic, antidiarrhoeal, antimicrobial, antispasmodic, vasorelaxant, cancer-chemopreventive, cytotoxic, toxicological, bioinsecticide, and repellent activities. A few of these studies have been carried out with isolated compounds from Tithonia species, but the majority has been conducted with different extracts. The relationship between the biological activity and the toxicity of compounds isolated from the plants of this genus as well as T. diversifolia extracts still remains unclear, and mechanisms of action remain to be determined. |
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Authors:
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Daniela A Chagas-Paula; Rejane B Oliveira; Bruno A Rocha; Fernando B Da Costa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 9 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 210-35 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich. |
Affiliation:
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Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Av. do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil, (phone: +55-16-36020661; fax: +55-16-36024879). |
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