Document Detail


Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).
MedLine Citation:
PMID:  22215136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/OBJECTIVES: It has been recognized that certain long-chain polyunsaturated fatty acids (LC-PUFAs) are involved in inflammation and its resolution. It has also been shown that ethnicity may be a factor in affecting systemic inflammation, and limited evidence suggests it may influence plasma LC-PUFA composition. Given the links among these three factors, we aim to determine ethnicity-based differences in plasma LC-PUFA composition among White, Black, Hispanic and Chinese participants, and whether such differences contribute to variations in markers of inflammation and endothelial activation in a sub-cohort of the Multi-Ethnic Study of Atherosclerosis (MESA).
SUBJECTS/METHODS: Plasma phospholipid LC-PUFAs levels (%) were determined in 2848 MESA participants using gas chromatography-flame ionization detection. Enzyme immunoassays determined inflammatory markers levels for high-sensitivity C-reactive protein (n=2848), interleukin-6 (n=2796), soluble tumor necrosis factor-α receptor type 1 (n=998), and endothelial activation markers soluble intercellular adhesion molecule-1 (n=1192) and soluble E-selectin (n=998). The modifying influence of ethnicity was tested by linear regression analysis.
RESULTS: Chinese adults were found to have the highest mean levels of plasma eicosapentaenoic acid (EPA, 1.24%) and docosahexaenoic acid (DHA, 4.95%), and the lowest mean levels of γ-linolenic (0.10%), dihomo-γ-linolenic (DGLA, 2.96%) and arachidonic (10.72%) acids compared with the other ethnicities (all P ≤ 0.01). In contrast, Hispanics had the lowest mean levels of plasma EPA (0.70%) and DHA (3.49%), and the highest levels of DGLA (3.59%; all P ≤ 0.01). Significant differences in EPA and DHA among ethnicities were attenuated following adjustment for dietary non-fried fish and fish oil supplementation. Ethnicity did not modify the associations of LC-PUFAs with markers of inflammation or endothelial activation (all P (interaction)>0.05).
CONCLUSIONS: The absence of a modifying effect of ethnicity indicates that the putative benefits of LC-PUFAs with respect to inflammation are pan-ethnic. Future longitudinal studies may elucidate the origin(s) of ethnicity-based differences in LC-PUFA composition and whether certain patterns, that is, high plasma levels of DGLA and low levels of EPA/DHA, contribute to inflammation-associated health outcomes.
Authors:
B T Steffen; L M Steffen; R Tracy; D Siscovick; D Jacobs; K Liu; K He; N Q Hanson; J A Nettleton; M Y Tsai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-04
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  66     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-02     Completed Date:  2012-08-16     Revised Date:  2014-08-13    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  600-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
8,11,14-Eicosatrienoic Acid / blood
Aged
Arachidonic Acid / blood
Asian Continental Ancestry Group
Atherosclerosis / blood*,  ethnology
Biological Markers / blood
Diet
Dietary Fats / blood*
Dietary Supplements
Docosahexaenoic Acids / blood
Eicosapentaenoic Acid / blood
Endothelium, Vascular*
Fatty Acids, Unsaturated / blood*
Female
Humans
Inflammation / blood*,  ethnology
Linear Models
Male
Middle Aged
Nutritional Status*
Phospholipids / blood*,  chemistry
Grant Support
ID/Acronym/Agency:
N01 HC095159/HC/NHLBI NIH HHS; N01 HC095160/HC/NHLBI NIH HHS; N01 HC095161/HC/NHLBI NIH HHS; N01 HC095162/HC/NHLBI NIH HHS; N01 HC095163/HC/NHLBI NIH HHS; N01 HC095164/HC/NHLBI NIH HHS; N01 HC095165/HC/NHLBI NIH HHS; N01 HC095166/HC/NHLBI NIH HHS; N01 HC095167/HC/NHLBI NIH HHS; N01 HC095168/HC/NHLBI NIH HHS; N01 HC095169/HC/NHLBI NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95166/HC/NHLBI NIH HHS; N01-HC-95167/HC/NHLBI NIH HHS; N01-HC-95168/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Dietary Fats; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 25167-62-8/Docosahexaenoic Acids; 27YG812J1I/Arachidonic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid; AAN7QOV9EA/Eicosapentaenoic Acid
Comments/Corrections

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