Document Detail

Ethnic variation in lower oesophageal sphincter pressure and length.
MedLine Citation:
PMID:  18616647     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oesophageal manometry (OM) is used to diagnose oesophageal motor disorders. Normal values of OM among United States ethnic groups are only available for Hispanic Americans (HA). AIM: To obtain normal values of OM in adult African American (AA) volunteers, compare these with those obtained in HA and non-Hispanic white (nHw) volunteers to determine if ethnic variation in normal oesophageal motor function exists. METHODS: Healthy AA, HA and nHw were recruited from the Jacksonville metropolitan area. Ethnicity was self-reported. Exclusion criteria were symptoms suggestive of oesophageal disease, medication use or concurrent illness affecting OM. All underwent OM using a solid-state system with wet swallows. Resting lower oesophageal sphincter (LOS) pressure and LOS length were measured at mid-expiration, while per cent peristaltic contractions, distal oesophageal contraction velocity, amplitude and duration were measured after 5 cc water swallows. RESULTS: Fifty-six AA, 20 HA and 48 nHw were enrolled. All completed OM. AA had significantly higher resting LOS pressure, LOS length and distal oesophageal contraction duration than nHw (P < 0.05). CONCLUSIONS: Significant ethnic exist in OM findings between AA and nHw. These underscore the need for ethnic specific reference values for OM to allow for correct diagnosis of oesophageal motor disorders in AA.
K J Vega; T Langford-Legg; M M Jamal
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Publication Detail:
Type:  Journal Article     Date:  2008-07-04
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  28     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-14     Completed Date:  2008-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  655-9     Citation Subset:  IM    
Division of Gastroenterology, University of Florida Health Science Center/Jacksonville, Jacksonville, FL 32207, USA.
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MeSH Terms
African Americans / ethnology*
Esophageal Motility Disorders / diagnosis*,  ethnology
Esophageal Sphincter, Lower / physiology*
European Continental Ancestry Group / ethnology*
Hispanic Americans / ethnology*
Middle Aged
Muscle Contraction / physiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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