Document Detail


Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study.
MedLine Citation:
PMID:  15226165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Two ethnically different, community-based samples of hypertensive adults were evaluated to determine the prevalence of dyslipidemia and how often dyslipidemia is drug-treated and controlled by such treatment. METHODS: We studied 1286 non-Hispanic black hypertensive subjects from Jackson and 1070 non-Hispanic white hypertensive subjects from Rochester who participated in the Genetic Epidemiology Network of Arteriopathy study. Subjects were categorized according to presence of coronary heart disease and risk factors for coronary heart disease. RESULTS: Prevalence of dyslipidemia was significantly greater among whites than blacks (women, 64.7% vs 49.5%; and men, 78.4% vs 56.7%; P<.001 for both) and among men than women (P</=.02 in each ethnic group). Among dyslipidemic subjects, treatment with lipid-regulating drugs was significantly more common among whites than blacks (women, 25.4% vs 16.4%, P =.001; and men, 32.6% vs 12.8%; P<.001), and among whites, treatment was significantly more common among men than women (P =.03). With drug treatment, control of dyslipidemia varied from 33.9% (white men) to 51.9% (black men), but the differences among ethnic-sex groups were not statistically significant. CONCLUSIONS: Dyslipidemia is highly prevalent in hypertensive adults. Fewer than one third of these adults are drug-treated, and fewer than half of those treated achieve recommended goals. Our findings suggest that an alarming 9 of 10 dyslipidemic hypertensive adults have untreated or undertreated dyslipidemia.
Authors:
John G O'Meara; Sharon L R Kardia; Jeffrey J Armon; C Andrew Brown; Eric Boerwinkle; Stephen T Turner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  164     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-30     Completed Date:  2004-08-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1313-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Pharmacy Services, Mayo Clinic and Foundation, Rochester, Minn, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Aged
Antilipemic Agents / therapeutic use
Biological Markers / blood
Cholesterol, LDL / blood
Coronary Disease / drug therapy,  epidemiology,  prevention & control
Drug Therapy, Combination
Ethnic Groups*
European Continental Ancestry Group
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hyperlipidemias / drug therapy,  ethnology*,  prevention & control*
Hypertension / drug therapy,  ethnology*,  prevention & control*
Male
Middle Aged
Prevalence
Risk Factors
Sex Factors
Treatment Outcome
United States / ethnology
Grant Support
ID/Acronym/Agency:
R01 HL53330/HL/NHLBI NIH HHS; R01 HL68737/HL/NHLBI NIH HHS; U01 HL54457/HL/NHLBI NIH HHS; U01 HL54464/HL/NHLBI NIH HHS; U01 HL54481/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Biological Markers; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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