Document Detail

Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians.
MedLine Citation:
PMID:  7591259     Owner:  NLM     Status:  MEDLINE    
To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-II) carriers among South American native Indians, we analyzed HLA DRB1*-DQB1* haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-I-carrying Andes natives had one of the 5 HLA haplotypes: DRB1*-DQB1* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRB1*-DQB1* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These results suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections.
T Fujiyoshi; S Yashiki; C Fujiyama; M Kuwayama; H Miyashita; H Ohnishi; M Blank; V Zaninovic; A Blank; L Cartier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  63     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-28     Completed Date:  1995-12-28     Revised Date:  2010-10-15    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  510-5     Citation Subset:  IM; X    
Department of Virology, Faculty of Medicine, Kagoshima University, Japan.
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MeSH Terms
Base Sequence
Carrier State / virology*
HLA-DQ Antigens / genetics
HLA-DR Antigens / genetics
Haplotypes / genetics*
Human T-lymphotropic virus 1 / genetics*
Human T-lymphotropic virus 2 / genetics*
Indians, South American / genetics*
Molecular Sequence Data
Reg. No./Substance:
0/HLA-DQ Antigens; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen

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