|Ethnic heterogeneity in the longitudinal effects of placental vascular blood flow on birthweight.|
|PMID: 17826729 Owner: NLM Status: MEDLINE|
|OBJECTIVE: Our goals were: (1) to estimate the longitudinal trends in uterine artery (UtArt) and umbilical artery (UmArt) resistance indices (RIs) in different ethnic strata; (2) to estimate time-dependent changes across gestation in the influence of variation in UtArt and UmArt RI on variation in birthweight in different ethnic strata; and (3) to determine the optimum set of UtArt and UmArt RIs for predicting birthweight in different ethnic strata.
STUDY DESIGN: Analyses were carried out on data collected in a prospective study of 535 multiethnic gravidas recruited from the Cedars-Sinai Medical Center (Los Angeles, CA). Baseline maternal characteristics were recorded at time of entry into the study. UtArt and UmArt RIs were measured on 3 occasions during pregnancy (visit 1, 16-20 weeks' gestation; visit 2, 21-29 weeks' gestation; and visit 3, 30-36 weeks' gestation). The outcome for this study was gestational age-adjusted birthweight (aBW).
RESULTS: The average UtArt and UmArt RI decreased steadily across gestation for all ethnicities. The average UtArt RI at each visit and the average rate of change between visits were not significantly different among the ethnicities. However, the UmArt RI measured at visit 3 and its rate of change in the last trimester were significantly different among the ethnic groups (P < .02). After adjustment for traditional risk factors for fetal growth restriction, the magnitude and rate of change of UtArt RI significantly predicted aBW only in Hispanic women, whereas the magnitude and rate of change of UmArt RI predicted aBW only in African American women. The most parsimonious combination of UtArt and UmArt RI measurements at visits 1, 2, and 3 that predicted statistically significant variation in aBW differed by ethnicity.
CONCLUSION: The relationships between aBW and longitudinally collected measures of UtArt and UmArt RI depend on the context defined by ethnicity and time of measurement after adjusting for a parsimoniously selected subset of traditional risk factors.
|Vinod K Misra; Calvin J Hobel; Charles F Sing|
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|Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-09-12|
|Title: American journal of obstetrics and gynecology Volume: 198 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2008 Jan|
|Created Date: 2008-01-01 Completed Date: 2008-01-28 Revised Date: 2013-06-06|
Medline Journal Info:
|Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States|
|Languages: eng Pagination: 72.e1-8 Citation Subset: AIM; IM|
|Division of Medical Genetics, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA.|
|APA/MLA Format Download EndNote Download BibTex|
African Americans / statistics & numerical data
Birth Weight / physiology*
Blood Flow Velocity
Ethnic Groups / statistics & numerical data*
European Continental Ancestry Group / statistics & numerical data
Hispanic Americans / statistics & numerical data
Placental Circulation / physiology*
Predictive Value of Tests
Umbilical Arteries / physiology
Uterus / blood supply
|K08 HD045609-04/HD/NICHD NIH HHS; K08-HD045609/HD/NICHD NIH HHS; P01 HD047609/HD/NICHD NIH HHS; P01 HD047609-03/HD/NICHD NIH HHS; P01-HD047609/HD/NICHD NIH HHS; R01 HD029553/HD/NICHD NIH HHS|
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