Document Detail

Ethnic differences in resistance artery contractility of normotensive pregnant women.
MedLine Citation:
PMID:  20511407     Owner:  NLM     Status:  MEDLINE    
Black women are at a greater risk to develop hypertension during pregnancy, with a 4.5 times higher rate of fatal preeclampsia than white women. Therefore, it is important to identify factors that may affect this risk. Our group previously proposed that high activity of the central regulatory enzyme of energy metabolism, creatine kinase (CK), may increase ATP-buffering capacity and lead to enhanced vascular contractility and reduced nitric oxide bioavailability. Therefore, we assessed microvascular contractility characteristics in isolated resistance arteries from self-defined black and white normotensive pregnant women using a Mulvany-Halpern myograph. Additionally, morphology was assessed with electron microscopy. Resistance-sized arteries obtained from omentum donated during cesarean sections (11 black women and 20 white women, mean age: 34 yr) studied in series showed similar morphology but significantly greater maximum contractions to norepinephrine (10(-5) M) in blacks [14.0 mN (1.8 SE)] compared with whites [8.9 mN (1.4 SE), P = 0.02]. Furthermore, we found greater residual contractility after the specific CK inhibitor dinitrofluorobenzene (10(-6) M) in black women [55% (6 SE)] compared with white women [28% (4 SE), P = 0.001] and attenuated vasodilation after bradykinin (10(-7) M) in black women [103% (6 SE)] compared with white women [84% (5 SE), P = 0.023], whereas responses to sodium nitroprusside (10(-4) M) and amlodipine (10(-6) M) were similar. We conclude that compared with white women, normotensive pregnant black women display greater resistance artery contractility and evidence of higher vascular CK activity with attenuated nitric oxide synthesis. These findings in normotensives may imply that the black population is at risk for a further incline in pregnancy-related hypertensive disorders.
L M Brewster; Z Taherzadeh; S Volger; J F Clark; T Rolf; H Wolf; E Vanbavel; G A van Montfrans
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-05-28
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  299     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H431-6     Citation Subset:  IM    
Depts. of Internal and Vascular Medicine, F4-222, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
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MeSH Terms
Adenylate Kinase / antagonists & inhibitors,  metabolism
African Continental Ancestry Group*
Arteries / physiology
Creatine Kinase / antagonists & inhibitors,  metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology
European Continental Ancestry Group*
Health Status Disparities*
Hypertension, Pregnancy-Induced / ethnology*,  metabolism,  physiopathology
Microscopy, Electron, Transmission
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism
Omentum / blood supply*
Risk Assessment
Risk Factors
Vascular Resistance*
Vasoconstriction* / drug effects
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; EC Oxide Synthase; EC Kinase; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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